Abstract 14579: Predictors of In-Hospital Mortality in Coronary Artery Dissection Patients: An Insight From the National Inpatient Sample Database

Abstract

Background: There is a paucity of data on predictors of mortality in all-cause coronary artery dissection patients. The purpose was to study the baseline characteristics, associated co-morbidities, and in-hospital mortality in coronary artery dissection patients using the Healthcare Cost and Utilization Project National Inpatient Sample database. Methods: The Healthcare Cost and Utilization Project administrative longitudinal database contains encounter-level information on inpatient stays, emergency department visits, and ambulatory surgery in all U.S. hospitals. We performed a cross-sectional analysis on 25005 patients diagnosed with coronary artery dissection during hospitalization from January 2016 to December 2018. The primary outcome was in-hospital mortality. Results: Of the total patient population, 25005 patients were found to have coronary artery dissection. All patients with ages ≥ 18 were included in the study (24980). The observed overall in-hospital mortality was 6.0% (1498 patients out of 24980). The higher mortality was observed in age group >80 years when compared to the age group <40 years (adjusted odds ratio: 8.5; 95% confidence interval: 5.7 to 12.4; p-value < 0.01). Patients with peripheral vascular disease (adjusted odds ratio: 2.0; 95% confidence interval: 1.7 to 2.3; p-value < 0.01) and cardiogenic shock (adjusted odds ratio: 10.8; 95% confidence interval: 9.5 to 12.2; p-value < 0.01) showed higher mortality (Table 1,2). Conclusion: To the best of our knowledge, this is the largest population-based study investigating the predictors of in-hospital mortality in all-cause coronary artery dissection patients. Our analysis showed higher mortality with increasing age and in patients who developed cardiogenic shock and those with peripheral vascular disease.