2016
DOI: 10.1158/1538-7445.am2016-2679
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Abstract 2679: Induction of β-globin protects circulating tumor cells from oxidative stress during dissemination

Abstract: Identification of candidate metastasis genes has traditionally resulted from comparison of primary and metastatic tumor specimens. However, Circulating Tumor Cells (CTCs) contain metastatic precursors that are present transiently in the bloodstream and their analysis may reveal additional pathways that are induced for a limited time, as they invade and survive within the vasculature. By comparing transcriptome profiles of CTCs from breast, prostate and lung cancers with their primary tumor of origin, we observ… Show more

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Cited by 7 publications
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“…Recently, an RBP, the RNA binding motif single stranded interacting protein 3 (RBMS3) is found to be located at 3p24-p23, where is often found deleted or mutated in cancers, suggesting its potential role in tumor suppressing [17]. Moreover, downregulation of RBMS3 in esophageal squamous cell carcinoma [18], lung squamous cell carcinoma [19], nasopharyngeal carcinoma [20] and gastric carcinoma [21] are frequently correlated with poor prognosis in patients and loss of RBMS3 contributed to chemoresistance in epithelial ovarian cancer [22]. Furthermore, RBMS3 was found to inhibit the proliferation and tumorigenesis of breast cancer cells, at least in part, through inactivation of the Wnt/β-catenin signaling pathway [23].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, an RBP, the RNA binding motif single stranded interacting protein 3 (RBMS3) is found to be located at 3p24-p23, where is often found deleted or mutated in cancers, suggesting its potential role in tumor suppressing [17]. Moreover, downregulation of RBMS3 in esophageal squamous cell carcinoma [18], lung squamous cell carcinoma [19], nasopharyngeal carcinoma [20] and gastric carcinoma [21] are frequently correlated with poor prognosis in patients and loss of RBMS3 contributed to chemoresistance in epithelial ovarian cancer [22]. Furthermore, RBMS3 was found to inhibit the proliferation and tumorigenesis of breast cancer cells, at least in part, through inactivation of the Wnt/β-catenin signaling pathway [23].…”
Section: Introductionmentioning
confidence: 99%