2022
DOI: 10.1158/1538-7445.am2022-2827
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Abstract 2827: Non-viral gene editing enables multiplex single-step precision genome engineering for adoptive cell therapies

Abstract: PACT Pharma has developed a robust single-step, targeted, non-viral method for the manufacturing of personalized adoptive cells therapies for the treatment of solid cancers (NCT03970382). For this, we insert and express a neoepitope-specific T cell receptor (neoTCR) from the endogenous locus while simultaneously abolishing the expression of endogenous TCR. This results in neoTCR-specific T cells in which neoTCR expression is naturally regulated and not impeded by competition for CD3 by the endogenous TCR. … Show more

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