2017
DOI: 10.1158/1538-7445.am2017-3645
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Abstract 3645: Preclinical characterization of a multi-specific DARPin molecule targeting PD1 and VEGF

Abstract: Background: Combination therapy of immune-modulating drugs with modalities targeting tumor cells directly or the tumor stroma are increasing in clinical investigation and practice. In particular, the combination of immune checkpoint modulators targeting PD1 and molecules targeting the tumor stroma, like anti-VEGF therapeutics, are being utilized in multiple permutations and have shown promising results. We have developed a new class of protein therapeutics DARPin® molecules for simultaneous targeting of PD1 an… Show more

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