Abstract:Since methotrexate (MTX) resistance of osteosarcoma is a frequent cause of poor prognosis, new treatment strategies are needed to overcome this recalcitrant problem. The present study investigated if MTX resistance increased malignancy of osteosarcoma cells and its possible mechanism, via histone-H3 lysine-methylation status. We also propose a new therapeutic strategy for MTX resistant osteosarcoma. MTX resistant 143B osteosarcoma cells (143B-MTXR) were established from 143B parental osteosarcoma cells (143B-P… Show more
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