2012
DOI: 10.1158/1538-7445.am2012-4122
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Abstract 4122: Induction of steroid sulfatase expression by bacterial lipopolysaccharides in human prostate cancer cells: Possible role of STS in tumor cell migration

Abstract: Steroid sulfatase (STS) is responsible for the conversion of estrone sulfate to estrone that can stimulate growth in endocrine-dependent tumors such as breast and prostate cancer. Although STS is considered as a therapeutic target for the estrogen-dependent diseases, cellular function of STS are still not clear. Previously, we found that tumor necrosis factor (TNF)-α significantly enhances steroid sulfatase expression in PC-3 human prostate cancer cells through PI3K/Akt-dependent pathways. Here, we studied whe… Show more

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