2010
DOI: 10.1158/1538-7445.am10-4532
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Abstract 4532: Nucleolin inhibits Hdm2-mediated p53 ubiquitination using multiple interactions

Abstract: Nucleolin is a multifunctional abundant nucleolar protein whose transcriptional expression is trans-activated by the proto-oncogene c-myc during exponential cellular growth. This non-ribosomal protein has defined roles in ribosomal RNA processing and transcriptional regulation of various genes including rRNA. Following cellular stress, nucleolin has been shown to inhibit chromosomal replication and to relay nucleolar stress signals mediated by its sub-nuclear re-localization. Thus, nucleolin has been demonstra… Show more

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