Abstract:There is overwhelming evidence that tyrosine kinases play an important role in cancer development. As a prototype of targeted therapy, tyrosine kinase inhibitors are now successfully applied to cancer treatment. However, as single agents, tyrosine kinase inhibitors have not achieved satisfactory results in the treatment of prostate cancer, principally due to their inability to efficiently kill tumor cells. Our lab has been interested in the role of the Src complex in prostate cancer progression including the i… Show more
“…Activation of autophagy has been shown to prevent cell death, while inhibition of autophagy can enhance reagent-induced cell death 48,49 . As shown in many studies, autophagy promotes neuroprotection, whereas inhibiting autophagy reduces retinal degeneration caused by protein misfolding and stimulating autophagy has been reduced photoreceptor death 50 , this is consistent with our experimental results.…”
Purpose: Autophagy pathway might be involved in the production of pro-inflammatory cytokines and apoptosis in HG-stimulated Müller cells, though details of the mechanism remain largely not currently known.
“…Activation of autophagy has been shown to prevent cell death, while inhibition of autophagy can enhance reagent-induced cell death 48,49 . As shown in many studies, autophagy promotes neuroprotection, whereas inhibiting autophagy reduces retinal degeneration caused by protein misfolding and stimulating autophagy has been reduced photoreceptor death 50 , this is consistent with our experimental results.…”
Purpose: Autophagy pathway might be involved in the production of pro-inflammatory cytokines and apoptosis in HG-stimulated Müller cells, though details of the mechanism remain largely not currently known.
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