2012
DOI: 10.1161/hyp.60.suppl_1.a523
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Abstract 523: Sodium Nitrite Therapy Augments Ischemia-Induced Neovascularization and Blood Flow Recovery in Different Models of Hypertension

Abstract: Background: Arterial hypertension is a major risk factor that can lead to exacerbation of peripheral vascular disease due, in part, to endothelial dysfunction. Because sodium nitrite (SN) can be converted to nitric oxide (NO), which counteracts endothelial dysfunction, we explored the effect of nitrite on neovascularization following hind-limb ischemia in different models of hypertension (HT). METHODS: Chronic infusion of angiotensin-II (Ang-II, 400ng/K… Show more

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