Abstract 5563: Docetaxel-induced mucositis in breast cancer patients: Association with plasma alpha-1-acid glycoprotein level and SLCO1B3 genotype

Jabir, Rafid Salim; Ho, Gwo Fuang; Anuar, Muhammad Azrif; Stanslas, Johnson

doi:10.1158/1538-7445.am2014-5563

Cited by 1 publication

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“…Current clinical interest in AGP is related to its abundance in the serum of cancer patients. The serum concentration of AGP affects the pharmacokinetics and dynamics of the chemotherapeutic drug docetaxel and may predict a patient's reaction to the therapy [ 153 ]. The effect of AGP on docetaxel therapy is currently being examined in a large scale clinical trial ( Table 2 ).…”

Section: Carbohydrates As Potential Serum Biomarkersmentioning

confidence: 99%

Glycosylation-Based Serum Biomarkers for Cancer Diagnostics and Prognostics

Kirwan

Utratna

O’Dwyer

et al. 2015

BioMed Research International

181

143

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Cancer is the second most common cause of death in developed countries with approximately 14 million newly diagnosed individuals and over 6 million cancer-related deaths in 2012. Many cancers are discovered at a more advanced stage but better survival rates are correlated with earlier detection. Current clinically approved cancer biomarkers are most effective when applied to patients with widespread cancer. Single biomarkers with satisfactory sensitivity and specificity have not been identified for the most common cancers and some biomarkers are ineffective for the detection of early stage cancers. Thus, novel biomarkers with better diagnostic and prognostic performance are required. Aberrant protein glycosylation is well known hallmark of cancer and represents a promising source of potential biomarkers. Glycoproteins enter circulation from tissues or blood cells through active secretion or leakage and patient serum is an attractive option as a source for biomarkers from a clinical and diagnostic perspective. A plethora of technical approaches have been developed to address the challenges of glycosylation structure detection and determination. This review summarises currently utilised glycoprotein biomarkers and novel glycosylation-based biomarkers from the serum glycoproteome under investigation as cancer diagnostics and for monitoring and prognostics and includes details of recent high throughput and other emerging glycoanalytical techniques.

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Section: Carbohydrates As Potential Serum Biomarkersmentioning

confidence: 99%