2020
DOI: 10.1158/1538-7445.am2020-6648
|View full text |Cite
|
Sign up to set email alerts
|

Abstract 6648: Racotumomab and PD-1 blockade combination exhibits an additive antitumor effect in a non-small cell lung cancer model

Abstract: N-glycolylneuraminic acid (NeuGc) is a sialic acid molecule present in mammalian cells as terminal constituents of membrane glycoconjugates such as gangliosides and glycoproteins. Although the role of NeuGc-containing glycoconjugates in human cancer is still under investigation, gangliosides such as NeuGcGM3 has been consistently reported as a tumor antigen in various epithelial and neuroectodermal malignancies, including non-small cell lung cancer (NSCLC). Interestingly, NeuGc-glycoconjugates are abundant in … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
0
0

Year Published

2023
2023
2023
2023

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 0 publications
0
0
0
Order By: Relevance
“…Enhanced sialylated N-glycolyl GM3 expression has been found in neuroblastoma and described as a useful specific target in immunotherapy. Racotumumab is also now used as second-line therapy in non-small-cell lung cancer and prolongs the overall survival of patients [105,106].…”
Section: Molecular and Cellular Consequences Of Sialome Targetingmentioning
confidence: 99%
“…Enhanced sialylated N-glycolyl GM3 expression has been found in neuroblastoma and described as a useful specific target in immunotherapy. Racotumumab is also now used as second-line therapy in non-small-cell lung cancer and prolongs the overall survival of patients [105,106].…”
Section: Molecular and Cellular Consequences Of Sialome Targetingmentioning
confidence: 99%