Abstract 993: Chemotherapy enhances exosome secretion via upregulation of cholesterol metabolism in acute myeloid leukemia

Chemotherapy Promotes Release of Exosomes Which Upregulate Cholesterol Synthesis and Chemoresistance in AML Blasts

“…In the recently published article entitled "Increased small extracellular vesicle secretion after chemotherapy via upregulation of cholesterol metabolism in acute myeloid leukemia" [8], we reported that exosomes play a critical role in AML progression by establishing and driving a vicious cycle of chemoresistance in leukemic blasts. The mechanisms involved in exosome-mediated chemoresistance of AML blasts to CT are largely unknown, but our data suggest that it may be related to the excessive sEV release by AML blasts.…”