2016
DOI: 10.1158/2326-6066.imm2016-a020
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Abstract A020: A novel synthetic CD40L plasmid adjuvant generates unique anti-HPV DNA vaccine induced responses that impact tumor growth

Abstract: The use of plasmid adjuvants encoding cytokine, chemokine or immune modulators to tailor vaccine-induced response is a strength of the DNA vaccine platform. Due to its role in both innate and adaptive immunity, we hypothesis that the co-delivery of plasmid encoded CD40 ligand (CD40L) could increase DNA vaccine responses. In its natural form, CD40L can occur as either a surface bound form or a cleaved/solubilized form. Thus, we sought to determine if different forms of pCD40L can influence cellular and humoral … Show more

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