Abstract A52: Koetjapic acid suppresses angiogenesis causing inhibition in VEGF expression

Abstract

Koetjapic acid is a naturally occurring ichthyotoxic compound which can be isolated from the stem bark of Sandricum keotjape. This is a large tree species that can be found widely in Malaysia and other tropical countries in Southeast Asia. In our studies, we found koetjapic acid to be strongly antiangiogenic causing significant inhibition in endothelial tube formation. The compound inhibited VEGFA expression and caused retardation in cell migration. Keotjapic acid also suppressed the activity of Hif-1a and up regulates TGFβ and NFκB activity. This suggests the potential use of Keotjapic acid to target ailments that is angiogenesis dependent. Citation Information: Cancer Prev Res 2010;3(12 Suppl):A52.

Koetjapic acid: unveiling its potential as a saviour in the realm of biological and medicinal properties, with a focus on anticancer mechanism of action

“…The antiangiogenic properties of KJA can be associated with its targeting of angiogenesis cascades. It exerts its antiangiogenic effects by inhibiting the formation of new blood cells, migration and differentiation of endothelial cells and expression of VEGF factor, which is the main positive angiogenic factor [ 45 , 46 ]. The metastasis is another significant event in carcinogenesis, which consists of multiple steps including cell survival, colony formation, migration and invasion.…”

“…Nassar et al have shown that treating KJA on Human Umbilical Vein Endothelial Cells (HUVECs) demonstrates its anti-angiogenic activity. KJA has been shown to have low-cytotoxicity against HUVECs with IC-50 of 40.97 μg/ml, where KJA was found to inhibit the vasculogenesis by alleviating the expression of VEGF, migration of endothelial cells as well as differentiation [ 3 , 4 , 11 , 50 , 51 ]. In another study, the pharmacokinetics of KJA were studied, and the anti-angiogenic role was investigated in EA.hy926 cell lines.…”