2015
DOI: 10.1158/1538-8514.pi3k14-b33
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Abstract B33: Understanding resistance mechanisms to PI3K/mTOR inhibitors in ovarian cancer model systems

Abstract: The combined use of computational models and experimental data is an emerging tool in systems biology to help explain the mechanism of resistance to various protein inhibitors in oncological medicine. Improved understanding of the signaling network dynamics may offer novel approaches to overcoming drug resistance. The aim of this study was to analyze the signaling dynamics of the PI3K/Akt/mTOR pathway in ovarian cancer cells after treatment with different PI3K/mTOR inhibitors. Systems computational approach wa… Show more

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