2010
DOI: 10.1158/0008-5472.sabcs10-p1-04-03
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Abstract P1-04-03: A Role for Cyclin D1 in Neoplastic Transformation in MCF-7 Breast Cancer Cells Post p14ARF-p53 Induced Senescence

Abstract: Many years of oncogenic insult and hormonal flux have important long-term implications for breast cancer emergence and progression. Premature-induced senescence is proposed to be a protective response against cancer development. We hypothesize that the senescence response can be subverted in some breast carcinomas, which exhibit latent hormone-dependent proliferative capacity. The ARF-p53 pathway has long been known to play an important role in tumour surveillance halting cell cycle progression … Show more

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