Abstract P144: Cardiovascular Risk Assessment in Western Honduras; An Epidemiological Perspective

Abstract

Background: Cardiovascular Disease (CVD) epidemiology varies significantly among Low and Middle-Income Countries. Honduras is the Central American country with the highest ischemic heart disease and CVD mortality rates. The objective of this study is to provide an epidemiologic perspective of CVD in Western Honduras by analyzing cardiovascular (CV) risk in a population of Hispanics/mestizos and calculating their predicted CVD mortality using Cardiovascular Risk Assessment Scores (CVRAS) such as AHA/ACC Pooled-Cohort Equations (PCEs), Framingham Risk Score (FRS) and Multi-Ethnic Study on Atherosclerosis (MESA) Risk Score. Methods: Data was derived from Torres et al study, which was a cross-sectional, primary-prevention study, including 382 subjects between 45-75 years, in Copán, Honduras, between November 2016 and January 2017. Results: Out of 379 subjects meeting inclusion criteria, 38% (143 of 379) were male and 62% (237 of 379) were female. Age was 57 ± 8.2 for men and 58 ± 7.7 for women. Prevalence of hypertension was 49.7% (71 of 143) in men and 47.7% (113 of 237) in women; 91.3% (168 of 184) were being treated. DM was present in 19% (27 of 143) of men and 22.1% (52 of 237) of women; 96.2% (75 of 79) were being treated. Obesity was 24.5% (35 of 143) in men and 24.1% (57 of 237) in women. Total cholesterol was ≥ 200 mg/dl in 63.1% (239 of 379) of subjects, 21.8% (52 of 239) were taking lipid-lowering medications. For men and women respectively; AHA/ACC-PCEs was ≥7.5% (high-risk) in 62.2% (89 of 143) and 29.8% (71 of 237), FRS was ≥20% in 46.2% (66 of 143) and 15.2% (36 of 237), and MESA Risk Score was ≥7.5% in 70.6% (101 of 143) and 17.7% (42 of 237). Conclusions: After collecting anthropometric and laboratory data, calculation of CVRAS showed significantly elevated rates of high-CV risk patients according to all 3 scores. This is the first study of its type in Honduras. Efforts should be made to aggressively reduce CVD risk factors, and follow this cohort of subjects to better understand CVD morbidity and mortality in Western Honduras.