Abstract P2-10-14: Triple Negative Breast Cancer: prognosis of triple-negative breast cancers and non-triple-negative breast cancers in a large registry of certified breast units

Abstract

Background: Prognosis of Triple-Negative Breast Cancer (TNBC) and non-TNBC has been evaluated predominantly in smaller subset of patients, and pooled analyses include various subsets of institutional standards. The West German Breast Center includes more than 200 certified breast units covering approx. 65 % of all breast cancer cases in the country. Material and Methods: We included all primary breast cancer cases of the last 3 years whenever patients received any kind of neoadjuvant or adjuvant chemotherapy in all certified breast units affiliated to the West German Breast Center. Data was submitted in a computer-based registry, where standardized data is prospectively collected. Data monitoring and benchmarking is held 6-monthly which guarantees a high standard of performance. Results: 34 675 non-TNBC patients achieved a DFS of 92,4 % at 2 years and 81,2 % at 3 years whereas out of 3728 TNBC-patients only 79 % were disease-free at 2 years and 57,4 % at 3 years. With regards to overall survival 97,3 % of non-TNBC patients were alive at 2 years and 92,2 % at 3 years, whereas 89,3 % TNBC-patients were alive at 2 years and 82,9 % at 3 years. Conclusion: In this large registry of certified breast units from the West German Breast Center we could underline the significant differences of prognosis as to DFS and OS between the non-TNBC and TNBC-subgroup of patients, displaying survival rates with modern 3rd generation chemotherapy, surgical treatment and radiotherapy in a controlled setting with prospectively collected data. To is, to our best knowledge, one of the largest data sets ever exploring the differences in prognosis between TNBC and non-TNBC-patients. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-10-14.

Translating the concept of intrinsic subtypes into an oncoplastic cohort of more than 1000 patients – predictors of recurrence and survival

“…Wang Y et al (2011) had similar results in their study. We also confirmed this in a previous study of a large cancer registry [21].…”

Breast conservative surgery and local recurrence

“…However, as stated in the recent SSO-ASTRO-Guidelines [47] margins need to be cleared in terms of "no ink on margins". Contrary to our findings in this cohort, there is evidence in other studies that unclear margins affect local recurrence and disease-free survival [48], especially in high-risk tumor subtypes, as we also found most recently in a cohort of 2037 patients with triple-negative breast cancer [49]. Traditional prognostic factors like T-size [50,51] in a cohort with a typical distribution of national mammography screening from 50 to 69 years with predominantly T1 and T2-tumors did not show a significant increase of recurrence rate from T1 to T2 stage.…”