2010
DOI: 10.1158/0008-5472.sabcs10-p4-06-03
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Abstract P4-06-03: TMEPAI a Novel Prognostic Marker for TGF-β Dependency of Metastatic Breast Cancers: Converts Tumor Suppressive TGF-β into a Tumor Promoter

Abstract: Background: The dependency of many aggressive and treatment resistant breast cancers on transforming growth factor-beta (TGF-β) for their growth and invasiveness is paradoxical because TGF-β is a classical tumor suppressor that inhibits the growth of normal and early neoplastic breast epithelium. Therefore, we addressed the question how does TGF-β signaling transform from its expected role as a tumor suppressor in early cancer to that of a tumor promoter that facilitates growth and invasion in the late stages?… Show more

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