Abstract P5-04-15: Inhibitory effects of calcitriol and the vitamin D analogue paricalcitol in combination with chemotherapy on the growth of HER2 overexpressing breast cancer cells
Abstract:Introduction: Despite recent advances in therapy, additional options for improving the outcomes of patients with HER2-overexpressing breast cancer (BC) are needed. The role of vitamin D in relation to BC outcomes is controversial. Both calcitriol and synthetic vitamin D analogues have been shown to increase sensitivity to chemotherapy in BC cell lines. In this study, we aimed to determine the effect of combined treatment with either calcitriol or the vitamin D analogue paricalcitol plus doxorubicin or paclitax… Show more
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