2017
DOI: 10.1158/1538-7445.sabcs16-p6-08-10
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Abstract P6-08-10: Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells

Abstract: It is widely recognized that inflammation promotes breast cancer invasion and metastasis. Given the complex nature of the breast tumor inflammatory microenvironment, much remains to be understood of the molecular mechanisms that govern these effects. We have previously shown that osteoprotegerin (OPG) knockdown in breast cancer cells resulted in reduced invasion and metastasis. Here we present novel insight into the role of OPG in inflammation-driven tumor progression in breast cancer cells by investigating th… Show more

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