2010
DOI: 10.1158/0008-5472.sabcs10-p6-15-16
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Abstract P6-15-16: LIV-1 Antibody-Drug Conjugate: A Novel Therapeutic Agent for Breast Cancer

Abstract: LIV-1, also known as SLC39A6 or ZIP6, is a member of the zinc transporter family and was first identified as an estrogen-inducible gene in breast cancer. LIV-1, as a downstream target of STAT3, promotes the epithelial to mesenchymal transition that is important in the malignant progression to metastasis. Consistent with its role in cancer, we determined by immunohistochemical (IHC) analysis that LIV-1 is expressed in 86% (n=22) of estrogen receptor-positive (ER+), hormone-treated tumors (both primary and metas… Show more

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“…The anti-human LIV1 antibodies were generated by immunizing BALB/C female mice with recombinant extracellular N-terminus (residues 1-329) of human LIV1 (h-LIV1) protein following the established protocol. 13 The spleen cells of immunized mice were later fused with the myeloma cell line SP2/0. The positive hybridoma cells, secreting LIV1specific antibodies, were screened by enzyme-linked immunosorbent assay (ELISA) and MDA-MB-231 cell-binding assay.…”
Section: Generation and Screening Of Murine Anti-liv1 Monoclonal Anti...mentioning
confidence: 99%
See 1 more Smart Citation
“…The anti-human LIV1 antibodies were generated by immunizing BALB/C female mice with recombinant extracellular N-terminus (residues 1-329) of human LIV1 (h-LIV1) protein following the established protocol. 13 The spleen cells of immunized mice were later fused with the myeloma cell line SP2/0. The positive hybridoma cells, secreting LIV1specific antibodies, were screened by enzyme-linked immunosorbent assay (ELISA) and MDA-MB-231 cell-binding assay.…”
Section: Generation and Screening Of Murine Anti-liv1 Monoclonal Anti...mentioning
confidence: 99%
“…Then, we designed new VL or VH by back mutation of different potentially important framework residues, which were described previously. 14,15 Subsequently, a series of whole humanized antibodies were obtained by pairing these VL and VH. Finally, affinity maturation antibodies were screened by protein binding and cell binding.…”
Section: Humanization and Maturation Of Anti-liv1 Mabsmentioning
confidence: 99%