Abstract PD06-10: Clinical Score for Deciding a Sentinel Node Biopsy(SNB) after Neo Adjuvant Treatment(NAC) for Breast Cancer

Abstract

Rationale: Selection of the best candidates for SNB after NAC remains under discussion. A retrospective study identified predictive factors for negative axillary dissection. A score was developed to select patients at high and low risk for metastatic SNB after NAC. Patients and methods: In 776 patients receiving NAC, clinico biologic patterns were evaluated by a multivariate logistic regression model in order to to predict the negativity of axillary dissection after surgical treatment. A 4 class score was created using the three significant factors: Initial clinical node status, oestrogen receptors positivity and clinical response to treatment. This model was then prospectively applied tto 180 patients between 2006-8 Results: The probability of having a negative axillary dissection in patients with a score 0, 0-2 and over 2 was respectively 80%, 56% and less than 50%. Conclusion: We developed a simple and reproducible score to predict the likelihood of having a negative axilla after NAC and consequently to better select the good candidates for SNB after NAC Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr PD06-10.