Abstract PR428

Chen, M.; Wang, Y.; Zhang, W.; Han, Xiuxin

doi:10.1213/01.ane.0000492815.84565.fd

Cited by 2 publications

(1 citation statement)

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“…The genes and their variants linked to differences in fatty acid absorption include fatty acid desaturase genes ( FADS1 , FADS2), the peroxisome proliferator-activated receptor genes ( PPARA, PPARG), the X-ray repair cross-complementing protein 1 gene ( XRCC1 ) and stearoyl-CoA desaturase ( SCD1). A number of studies have discussed the role that these genes play in the serum levels of LC-PUFA-omega-3 and omega-6 fatty acids, as well as the effects of various variants on metabolic pathways and how this impacts inflammation and cancer risk [94,95,96,97,98,99,100,101,102,103,104]. These studies show that the impact of these fatty acids—especially on inflammation—is also influenced by the person’s genotype.…”

Section: The Western Dietmentioning

confidence: 99%

A Personalised Dietary Approach—A Way Forward to Manage Nutrient Deficiency, Effects of the Western Diet, and Food Intolerances in Inflammatory Bowel Disease

2019

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This review discusses the personalised dietary approach with respect to inflammatory bowel disease (IBD). It identifies gene–nutrient interactions associated with the nutritional deficiencies that people with IBD commonly experience, and the role of the Western diet in influencing these. It also discusses food intolerances and how particular genotypes can affect these. It is well established that with respect to food there is no “one size fits all” diet for those with IBD. Gene–nutrient interactions may help explain this variability in response to food that is associated with IBD. Nutrigenomic research, which examines the effects of food and its constituents on gene expression, shows that—like a number of pharmaceutical products—food can have beneficial effects or have adverse (side) effects depending on a person’s genotype. Pharmacogenetic research is identifying gene variants with adverse reactions to drugs, and this is modifying clinical practice and allowing individualised treatment. Nutrigenomic research could enable individualised treatment in persons with IBD and enable more accurate tailoring of food intake, to avoid exacerbating malnutrition and to counter some of the adverse effects of the Western diet. It may also help to establish the dietary pattern that is most protective against IBD.

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