Abstract:Women diagnosed with breast cancer within 10 years of a completed pregnancy are 2~3x more likely to develop liver metastases than never-pregnant (nulliparous) patients, even after controlling for prognostic variables (Goddard 2017). This finding suggests a unique biology in the postpartum liver, a putative pre-metastatic niche, which makes postpartum patients more susceptible to liver metastases. In rodent models, we previously reported increased liver size, hepatocyte proliferation, and anabolic metabolism du… Show more
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