2014
DOI: 10.1161/str.45.suppl_1.tp152
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Abstract T P152: Correlates of Dolichoectasia in an Urban, Stroke-free Cohort: Results From the Northern Manhattan Study

Abstract: Introduction: Dolichoectasia (DE) is an arteriopathy characterized by tortuosity and/or dilatation of an artery. Some risk factors for atherosclerosis, such as male sex, age and hypertension are shared with DE, but the association of DE with subclinical measures, such as carotid plaque, is not clear. The objective of this study is to evaluate the frequency and determinants of DE in an unselected population. Methods: Surviving stroke-free participants fr… Show more

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“…Furthermore, there is clear association between larger arterial diameters and vascular risk factors, especially hypertension. 13,14 Although hypertension is highly prevalent in elderly populations, the heterogeneity of brain arterial phenotypes in people with vascular risk factors suggests that a specific genetic profile might partially be responsible for higher risk of brain arterial dilatation. Consequently, we hypothesize that in the general population less pathogenic but more frequent genetic variants may relate to brain arterial diameters.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, there is clear association between larger arterial diameters and vascular risk factors, especially hypertension. 13,14 Although hypertension is highly prevalent in elderly populations, the heterogeneity of brain arterial phenotypes in people with vascular risk factors suggests that a specific genetic profile might partially be responsible for higher risk of brain arterial dilatation. Consequently, we hypothesize that in the general population less pathogenic but more frequent genetic variants may relate to brain arterial diameters.…”
Section: Introductionmentioning
confidence: 99%