Abstract WMP46: Quantitative Electroencephalogram To Assess Neurovascular Coupling Post Endovascular Thrombectomy

Abstract

Introduction: Persistent neurovascular uncoupling may be associated with poor outcome in patients with ischemic stroke after successful recanalization. Quantitative electroencephalography (EEG) can be used to assess neuronal function. We assessed relation between degree of recanalization post-endovascular thrombectomy (EVT), quantitative EEG based parameters and severity of neurological deficits. Methods: Patients with acute ischemic stroke with large vessel occlusion in anterior circulation were enrolled. EEG was recorded using a modified Muse headband (InteraXon) before, immediately after and at 24 hours post-EVT. Pairwise-derived brain symmetry index (pdBSI) and delta-to-alpha ratio (DAR) were computed using Fitting Oscillation & one-over F (FOOOF) MATLAB wrapper. Results: A total of six patients with mean age 73.6±11.6 years and baseline median (IQR) NIHSS of 13.5 (11-15) were included. Expanded thrombolysis in cerebral infarction (eTICI) scores were 2b67 in one, 2c in two and 3 in three cases. Baseline EEG was recorded at 75 minutes (60-100) from arrival, second at 255 minutes (90-420) after recanalization and third at 28.5 hours (27-31) after recanalization. Four patients with improvement in NIHSS of >10 had 46.6±31.7% change in pdBSI at 24 h. One patient with NIHSS <10 improvement had -25.3% change in pdBSI. One patient with low baseline NIHSS (9) had 90.9% change in pdBSI. There was linear correlation between baseline infarct volume on perfusion studies and change in pdBSI at 24 h (r=0.86, p<0.0001, Figure 1). There was no difference in the DAR in the ipsilateral hemisphere pre-EVT, immediately post-EVT (p=0.6) and 24 h post-EVT (p=0.8). Conclusion: Preliminary data suggest return of neuronal function and clinical recovery may lag after successful recanalization, due to persistent neurovascular uncoupling. Higher baseline infarct volume may predict lower pdBSI change. Portable EEG may help characterise this novel treatment target.

A scoping review on the use of consumer-grade EEG devices for research

“…Three recent clinical studies show reliable applications in stroke patients. After observing good test-retest reliability [ 116 ], Rogers et al used the NeuroSky MindWave to determine distinct EEG profiles for patients who have experienced transient ischemic attack, ischemic stroke, or neither [ 117 ]; Wilkinson et al [ 118 ] used the interaXon Muse to accurately identify patients with large vessel occlusions, a diagnostic predictor of acute stroke; and Ishaque et al [ 119 ] used the interaXon Muse to characterise neuronal function and clinical recovery of stroke patients post-treatment.…”

A scoping review on the use of consumer-grade EEG devices for research

“…Three recent clinical studies show reliable applications in stroke patients. After observing good test-retest reliability [110], Rogers et al used the NeuroSky MindWave to determine distinct EEG profiles for patients who have experienced transient ischemic attack, ischemic stroke, or neither [111]; Wilkinson et al [112] used the interaXon Muse to accurately identify patients with large vessel occlusions, a diagnostic predictor of acute stroke; and Ishaque et al [113] used the interaXon Muse to characterise neuronal function and clinical recovery of stroke patients post-treatment.…”

“…profiles for patients who have experienced transient ischemic attack, ischemic stroke, or neither[111]; Wilkinson et al[112] used the interaXon Muse to accurately identify patients with large vessel occlusions, a diagnostic predictor of acute stroke; and Ishaque et al[113] used the interaXon Muse to characterise neuronal function and clinical recovery of stroke patients posttreatment.…”