Abstracts, 11th German Allergy Congress, Berlin, September 29 to October 1, 2016

Medizin, Springer

doi:10.1007/s40629-016-0130-4

Cited by 1 publication

(2 citation statements)

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“…Interestingly, 49 of 66 are mapped within the sequence stretch α-NAC/Hom s2 181−209 VKLVMSQANVSRAKAVRALKNNSNDIVNA, which has also been found to be immunogenic in our studies on autoallergic AD patients (51). Further, these data match our own findings, that MHC-I and MHC-II epitopes overlap in this region (52). Also epitopes of DSF70, Hom s3, and Hom s4 could be identified: Table 2 lists the most commonly identified epitopes and their appearances in the assays.…”

Section: Are Autoallergens Presented Via Mhc?—a Deeper Look Into the supporting

confidence: 91%

“…A possibility to downsize these laborious approaches is to apply prediction algorithms upfront that identify MHC-binding motifs within the primary sequence [like SYFPEITHI (49) and consensus (50)]. For hTrx and α-NAC/Hom s2 candidate T cell epitopes were presented to PBMC of sensitized donors, which led to modest but measureable T cell proliferation in sensitized donors and finally to the identification of MHC-I and MHC-II epitopes (51, 52).…”

Section: Autoreactive T Cells As a Results Of Crossreactivity Or De Nomentioning

confidence: 99%

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Autoimmunity (or Not) in Atopic Dermatitis

Roesner

Werfel

2019

Front. Immunol.

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Atopic dermatitis (AD), one of the most frequent inflammatory skin diseases worldwide, is believed to result from a disturbed skin barrier as well as aberrant immune reactions against per se harmless allergens. Starting mostly during childhood with a chronic, remitting relapsing course, the disease can persist into adulthood in about one fifth of patients. Immune reactions to self-proteins have been observed in AD patients already in the beginning of the Twentieth century, when human cellular extracts were shown to provoke skin lesions. However, the term “autoimmunity” has never been claimed, since AD is first and foremost an atopic disease. In contrast, this IgE-hallmarked autoreactivity was termed “autoallergy” and is ongoing discussed regarding its impact on the disease. Since severely affected patients tend to develop IgE-hypersensitivity reactions to numerous environmental allergens, the impact of immune responses to self-proteins is difficult to determine. On the other hand: any autoreactivity, irrespective of the magnitude, implicates the potential of driving the chronification of the disease while shaping the immune response. This review article revisits the observations made on autoallergy from an actual point of view and tries to approach the question whether these still point to a contribution to the disease.

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Section: Are Autoallergens Presented Via Mhc?—a Deeper Look Into the supporting

confidence: 91%