Abstracts

Rosemberg, Sérgio; Telxelra, M. J.; Alves, Venâncio Avancini Ferreira; Perry, James; Ang, Lee Cyn; Bilbao, Juan M.; Muller, Pavel; Min, Kyung Whan; Cashman, Robert E.; Brumback, Roger A.; Rao, C R; Deloso, D.; Anderson, V. M.; Seymour, Andrew; Wrzolek, Monika; Abdu, Afaf; Swanson, Richard M; Honavar, M.; Waters, K. B.; Wise, S. M.; Kubota, T.; Sato, Kazuhiro; Kabuto, Masanori; Nakagawa, T.; Kitai, Ryuheki; Nitta, Hisashi; Yamashita, J; Vital, C; Rivel, J; San-Galli, Fran??ois; Benjelloun, B.; Vital, Anne; Léger, François; Riemens, V.; Epardeau, B; Guérin, J.; Coindre, Jean‐Michel; Ruchoux, M. M.; Dhellemmes, P; Hamon, M.; Lecomte, M.; Hassoun, J.; Yagishita, Saburo; Kawano, Nobuyuki; Kameya, Toru; Bowman, Ryan; Liwnicz, Boleslaw H.; Peckham, Norman; Barbosa-Coutinho, Lígia Maria; Hilbig, L. M.; Hilbig, Arlete; Loiseau, H.; Mouton, L.; Delisle, H. B.; Rummens, C.; Akai, Fumiharu; Taneda, Mamoru; Iwasaki, Hideo; Suzuki, Yoshiaki; Tsanaclis, Alexandre; Aguiar, Paulo Henrique Pires de; Logullo, Ângela Flávia; Matamores, M. R.; Yacubian, A.; Komatsu, Hiroyoshi; Oka, Hiroyuki; Suwa, Tomonari; Stoltenburg-Didinger, G.; Gotzia, C.; Benndorf, G.; Kepes, John J.; Baba-Ahmed, R.; Wong, Kwok Yin; Raisanen, Jack M.; Taylor, Sherry L.; McDermott, Michael W.; Gutin, Phillip H.; Havlioglu, Necat; Manepalli, Anantha N.; Galindo, Lorenzo P; Sotelo‐Avila, Cirilo; Grosso, Leonard E.; Kavavattathayyil, S.; Chen, P.; Cook, Jay N.; Woodward, Diana E.; Tracqui, P.; Cruywagen, G. C.; Murray, Jason D.; Bartoo, Grace T.; Alvord, Ellsworth C.; Szymaś, Janusz; Jelonek, Jacek; Krawiec, Krzysztof; Słowiński, Roman; Coons, Stephen W.; Johnson, Peter C.; Uro, E.; Bousquet, P. H.; Delisle, M. B.; Rangueil, C. H. U.; Torp, Sverre Helge; Johannesen, E.; Lindboe, Christian Fredrik; Beil, Michael; Kato, Sciichi; Morita, Toshihiro; Kato, Masako; Herz, Fritz; Hirano, Atsushi; Ohama, Eisaku; Albuquerque, Luı́sa; Pimentel, José; Távora, L.; Antunes, N. L.; Weis, S.; Protopapa, D.; Maerz, U.; Winkler, Peter; Reulen, Hanns-Jürgen; Mehraein, P.; Xiao, Dingquan; Reifenberger, Julia; Reifenberger, Guido; Liu, Lu; James, C. David; Wechsler, W.; Collins, V. Peter; McLendon, Roger E.; Batra, Surinder K.; Friedman, Henry S.; Rasheed, Binish; Bigner, Darell D.; Bigner, S. K.; Patt, Stephan; Thiel, Gundula; Labrousse, F.; Néchaud, Béatrice de; Gomès, Danielle; Daumas-Duport, Cathérine; Allarmargot, C.; Dupouey, P.; Vrionis, Fotios D.; Qi, Peimin; Cherington, Van; Cano, G.; Wu, JK; Lampson, Lois A.; Chen, A.; Vortmeyer, Alexander O.; Slack, Ruth S.; Skerjanc, Ilona S.; Lach, B.; Craig, Jane; Jardine, Karen; McBurney, Michael W.; Macaulay, Robert J.B.; Dimitroulakos, Jim; Becker, Larry E.; Yeger, Herman; Rhodes, C. Harker; Honsinger, Charles; Sorenson, George D.; Goumnerova, Liliana; Segal, R. A.; Kwon, Young-Mi; Stiles, Charles D.; Pomeroy, SL; Guha, A.; Lau, Nathan; Pawson, A.; Engel, Ute; Gutowski, N. J.; Bevan, Karen; Noble, Mark; Gladson, Candece L.; Pijuan, Vivian; Olman, Mitchell A.; Gillespie, G. Yancey; Yacoub, I.; Yamasaki, Tomohiro; Enomoto, Koichi; Moritake, K; Akiyama, Y.; Kawahara, Masako; Maeno, T.; Merzak, Abderrahim; Parker, C.; Koocheckpour, S.; Gv, Sherbet; Pilkington, G. J.; Martin, K.; Akinwunmi, J.; Rooprai, H. K.; Kennedy, A.; Linke, A.; Ognjenovic, N.; Fujiwara, Takashi; Matsumoto, Yuusuke; Miyake, Katsuya; Shin, M.; Nagao, Sachi; Pulido-Cejudo, G.; Jamison, K.; Hugenholtz, H.; Campione-Piccardo, J.; Maidment, S. L.; Lins, Claudia; Takyia, C. M.; Garcia-Abreu, J.; Rodrigues, Flávio Freinkel; Duarte, F.; Chagas, Claudia Lopes Rodrigues; Chneiweiss, Hervé; Neto, Vivaldo Moura

doi:10.1007/bf01052669

Cited by 4 publications

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Composite Pleomorphic Xanthoastrocytoma and Ganglioglioma: Report of Four Cases and Review of the Literature

Perry

Giannini

Scheithauer

et al. 1997

The American Journal of Surgical Pathology

125

View full text Add to dashboard Cite

Composite pleomorphic xanthoastrocytoma (PXA)-ganglioglioma (GG) is a rare recently described entity. Only three examples have been documented, one of which showed evidence of malignant transformation. We report an additional four cases and update the literature. With the exception of an 82-year-old man, all patients have been under 30 years of age. The temporal lobe was involved in three cases and cerebellum in another three. Radiologic features were those common to PXA and GG. Histologically, all were "collision tumors" composed of abutting, although spatially distinct, PXA and GG components. In two cases, the second element was only recognized at reexcision or recurrence. Histologic anaplasia, always in the PXA component, was evident as brisk mitotic activity and/or necrosis in five cases. Of the seven patients, one died of disease 17 years after the onset of seizures and after multiple recurrences, the last of which largely resembled glioblastoma. We conclude that the composite PXA-GG is a rare neoplasm that shares many features of its individual components. In addition to its temporal lobe predilection, the cerebellum is frequently affected. As when it occurs in isolation, the PXA component of composite PXA-GG possesses the potential for malignant transformation.

show abstract

Composite Pleomorphic Xanthoastrocytoma and Ganglioglioma: Report of Four Cases and Review of the Literature

Perry

Giannini

Scheithauer

et al. 1997

The American Journal of Surgical Pathology

125

View full text Add to dashboard Cite

show abstract

Immunophenotype of Pleomorphic Xanthoastrocytoma

Giannini

Scheithauer

Lopes

et al. 2002

The American Journal of Surgical Pathology

106

View full text Add to dashboard Cite

Pleomorphic xanthoastrocytoma (PXA) is an uncommon tumor, often seizure-associated and occurring in the temporal lobe of young adults. Although its cells are considered astrocytic in nature, recent studies suggest the presence of neuronal differentiation and a possible relationship to glioneuronal neoplasms. We immunostained 40 cases of PXA, including two composite PXA-gangliogliomas (PXA-GG), with a panel of glial (glial fibrillary acidic protein, S-100 protein) and neuronal markers (class III beta-tubulin, synaptophysin, neurofilament proteins, MAP2, and chromogranin A). Conventional PXAs demonstrated immunoreactivity for glial fibrillary acidic protein (100% of cases), S-100 protein (100%), class III beta-tubulin (73%), synaptophysin (38%), NF proteins (18 and 8%), and MAP2 (8%). Chromogranin A stain was absent in all conventional PXA cases. Neoplastic ganglion cells in both PXA-GGs stained with class III beta-tubulin, synaptophysin, and chromogranin A. Ultrastructural studies, performed in nine cases, demonstrated neuronal features including microtubules, dense core granules, and/or clear vesicles largely limited to cell processes (two PXAs) and in the cytoplasm (PXA component of one PXA-GG). Although the essential nature of PXA is clearly and uniformly glial, the significance of the limited neuronal differentiation is unclear, as it is the relationship between conventional PXA and PXA-GG. We found no evidence that the former is a precursor of the latter.

show abstract

Ganglion cell tumors

Prayson¹

2006

Russell &Amp; Rubinstein's Pathology of Tumors of the Nervous System 7Ed

View full text Add to dashboard Cite

Abstracts

Cited by 4 publications

References 0 publications

Composite Pleomorphic Xanthoastrocytoma and Ganglioglioma: Report of Four Cases and Review of the Literature

Composite Pleomorphic Xanthoastrocytoma and Ganglioglioma: Report of Four Cases and Review of the Literature

Immunophenotype of Pleomorphic Xanthoastrocytoma

Ganglion cell tumors

Contact Info

Product

Resources

About