Abundantly expressed transcripts in the lymphoid organ of the black tiger shrimp, Penaeus monodon, and their implication in immune function

Pongsomboon, Siriporn; Wongpanya, Ratree; Tang, Sureerat; Chalorsrikul, Arthit; Tassanakajon, Anchalee

doi:10.1016/j.fsi.2008.07.010

Cited by 53 publications

(37 citation statements)

References 30 publications

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“…After secretion, TSPs can be incorporated into extracellular matrices in cell culture and in vivo (Raugi et al 1982;Jaffe et al 1983;Vischer et al 1985;DiCesare et al 1994a;Schlötzer-Schrehardt et al 2007; Adams Preechaphol et al Pongsomboon et al 2008. Alternatively, proteolytic fragments can be generated that either have a specific extracellular activity (Lee et al 2006), or are internalized for full degradation (see below) ( Fig.…”

Section: Degradation Of Tspsmentioning

confidence: 99%

The Thrombospondins

Adams¹,

Lawler²

2011

Cold Spring Harbor Perspectives in Biology

402

416

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Thrombospondins are evolutionarily conserved, calcium-binding glycoproteins that undergo transient or longer-term interactions with other extracellular matrix components. They share properties with other matrix molecules, cytokines, adaptor proteins, and chaperones, modulate the organization of collagen fibrils, and bind and localize an array of growth factors or proteases. At cell surfaces, interactions with an array of receptors activate celldependent signaling and phenotypic outcomes. Through these dynamic, pleiotropic, and context-dependent pathways, mammalian thrombospondins contribute to wound healing and angiogenesis, vessel wall biology, connective tissue organization, and synaptogenesis. We overview the domain organization and structure of thrombospondins, key features of their evolution, and their cell biology. We discuss their roles in vivo, associations with human disease, and ongoing translational applications. In many respects, we are only beginning to appreciate the important roles of these proteins in physiology and pathology.T hrombospondins (TSPs) comprise a conserved family of extracellular, oligomeric, multidomain, calcium-binding glycoproteins. In general, basal metazoa and protostomes encode a single TSP in their genomes and deuterostomes have multiple TSP genes. The TSPs of mammals have many complex tissue-specific roles, including activities in wound healing and angiogenesis, vessel wall biology, connective tissue organization, and synaptogenesis. These activities derive mechanistically from interactions with cell surfaces, growth factors, cytokines, or components of the extracellular matrix (ECM) that collectively regulate many aspects of cell phenotype. Emerging evidence on the functions of TSPs in invertebrates suggests that ancient functions include bridging activities in cell-cell and cell-ECM interactions. Knowledge of TSP domain structures provides a rational basis for understanding their roles in vivo and associations with human disease and is assisting ongoing translational applications. DOMAIN ARCHITECTURE AND DOMAIN STRUCTURESThe domain architectures of representative TSP polypeptides are shown in Figure 1A. The invariant carboxy-terminal regions comprise a series of EGF-like domains, thirteen calcium-binding type 3 repeats, and a carboxy-terminal domain structurally homologous to the L-type lectin

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Section: Degradation Of Tspsmentioning

confidence: 99%

The Thrombospondins

Adams¹,

Lawler²

2011

Cold Spring Harbor Perspectives in Biology

402

416

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“…Finally, a recent investigation of the neuropeptidome of the penaid shrimp Litopenaeus vannamei (Ma et al 2010) has identified transcripts encoding putative corazonin precursors from the lymphoid organ, a hemolymph filtering structure that is purported to play a role in innate immune control (van de Braak et al 2002;Pongsomboon et al 2008). Clearly, the interrelationship of the lymphoid organ and the hemolymph makes it a logical candidate for hormone production and release, warranting additional study as a potential endocrine organ.…”

Section: New Non-neuronal Sources Of Peptide Hormonesmentioning

confidence: 99%

Crustacean neuroendocrine systems and their signaling agents

Christie

2011

Cell Tissue Res

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Decapod crustaceans have long served as important models for the study of neuroendocrine signaling. For example, the process of neurosecretion was first formally demonstrated by using a member of this order. In this review, the major decapod neuroendocrine organs are described, as are their phylogenetic conservation and neurochemistry. In addition, recent advances in crustacean neurohormone discovery and tissue mapping are discussed, as are several recent advances in our understanding of hormonal control in this group of animals.

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“…In agreement with the higher expression of PmDWD in lymphoid organ upon leg amputation and WSSV infection, the PmDWD might function in controlling the clearance of foreign matters in the lymphoid organ by certain proteinases activated in response to infection. We have recently shown that the lysosomal cysteine proteinases; cathepsins B and cathepsins L, are abundantly expressed in the lymphoid organ [39]. These proteinases are believed to be involved in the functions of lymphoid organ and the PmDWD probably helps controlling their activities.…”

Section: Discussionmentioning

confidence: 99%