Abuse of fentanyl: An emerging problem to face

Kuczyńska, Katarzyna; Grzonkowski, Piotr; Kacprzak, Łukasz; Zawilska, Jolanta B.

doi:10.1016/j.forsciint.2018.05.042

Cited by 149 publications

(99 citation statements)

References 83 publications

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“…Fentanile bağlı yan etkilerin, özellikle solunum sistemi ile ilgili olanların geri çevrilmesinde opioid antagonisti olan nalokson kullanılmaktadır. 5 Ancak tablonun hızlı toparlaması nedeniyle hastamızda kullanıma gerek kalmamıştır. Olguya, zamanında ve uygun solunum desteği verilmesinin durumun ölümle sonuçlanmasını engellediği düşünülmektedir.…”

Section: Discussionunclassified

Fentanyl Patches Usage in Children; Inappropriate Use May Be Death

Alpcan¹,

Tursun²,

Ürem³

et al. 2020

cayd

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Section: Discussionunclassified

Fentanyl Patches Usage in Children; Inappropriate Use May Be Death

Alpcan¹,

Tursun²,

Ürem³

et al. 2020

cayd

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show abstract

“…In fact, opioid abuse is among the most consequential of the preventable public health threats (Gostin et al, 2017). Importantly, epidemiological and forensic medical data have shown a disturbing increase in the illicit use of fentanyl during recent years (Kuczyńska et al, 2018). For example, of 42,249 overdose deaths due to opioids in the USA in 2016, a total of 20,145 were associated with synthetic opioids other than methadone (often fentanyl), 15,446 were from heroin, 14,427 were from natural and semisynthetic opioids or prescription opioids, and 3,314 were from methadone (Manchikanti et al, 2018).…”

mentioning

confidence: 99%

“…Importantly, the death statistics involving fentanyl and the newly identified fentanyl analogs may only represent the "tip of the iceberg" since fentanyl derivatives are often not readily detected (Dai et al, 2019). Of interest, toxicological data show that fentanyl use is inextricably linked with polydrug use (Kuczyńska et al, 2018): Fentanyl is often mixed up with heroin ("fake heroin") to increase its potency at a little cost. Taken together, during recent years, fentanyl-related overdose deaths have skyrocketed and have thus become a huge contributor to the current overdose-death crisis in the USA (Spencer et al, 2019).…”

mentioning

confidence: 99%

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The Opioid-Overdose Crisis and Fentanyl: The Role of Online Information Seeking via Internet Search Engines

Arendt

2020

Health Communication

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Opioid abuse is a severe public health threat. Recent evidence points to a disturbing increase in the illicit use of fentanyl, a potent synthetic opioid, with abuse often involving illicitly produced opioids mixed with heroin. Public health experts have emphasized that there is an urgent need for new, effective harm-reduction strategies and technologies. We asked whether Internet search engines could contribute toward this goal. Using state-level data from the USA, we provide evidence for a cross-sectional and longitudinal statistical relationship between opioid-related overdose deaths and the number of Google searches using the term "fentanyl." This finding points to the relevance of Internet search engines: Userswho may be non-addicted vulnerable individuals, addicts, addicts' friends and family members, or physiciansdo in fact search for fentanyl online. We argue that during such searches, an info box including a warning (i.e., awareness material to educate users about the risks) and a help message (i.e., references to professional help) can be presented to target users and possibly prevent both unintentional and suicidal overdoses. Even if this info box only helps some users, the high number of daily Google searches renders this a promising public health intervention to supplement other opioid harm-reduction strategies.

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“…KEYWORDS: forensic science, forensic toxicology, fentanyl, transdermal patch, whole blood, QuEChERS, ultra-high-performance liquid chromatography-tandem mass spectrometry Fentanyl is a synthetic l-opioid receptor agonist, is approximately >100 times more potent than morphine per dose (1,2). It has been widely used for anesthesia and to manage intense chronic pain (2,3). Fentanyl has been available for human application, both in the oral transmucosal and in the parenteral (such as transdermal) form (1).…”

mentioning

confidence: 99%

A Fatal Case of Poisoning with Fentanyl Transdermal Patches in Japan

Nara

Yamada

Saka

et al. 2019

Journal of Forensic Sciences

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Fentanyl transdermal patches have been used to treat cancer‐ and noncancer‐related chronic pain. However, its inappropriate or illegal application may cause fatal poisoning. We herein present the case of a Japanese woman in her 40s who was found dead with seven 25‐μg/h fentanyl transdermal patches on her body. We established a detailed toxicological analysis procedure to quantify fentanyl, and its metabolite norfentanyl, and other drugs (acetaminophen, allylisopropylacetylurea, celecoxib, estazolam, promethazine, and sertraline) in human whole blood by ultra‐high‐performance liquid chromatography–tandem mass spectrometry. The measured fentanyl and norfentanyl concentrations in the femoral and cardiac blood were 0.051 and 0.072 μg/mL and 0.033 and 0.076 μg/mL, respectively. The decedent's fentanyl concentrations were consistent with previously reported postmortem blood levels for fatal cases of poisoning by fentanyl transdermal patches. Based on the decedent's case history, autopsy findings, and toxicological analyses, the cause of death was identified as intoxication with transdermal fentanyl.

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Abuse of fentanyl: An emerging problem to face

Cited by 149 publications

References 83 publications

Fentanyl Patches Usage in Children; Inappropriate Use May Be Death

Fentanyl Patches Usage in Children; Inappropriate Use May Be Death

The Opioid-Overdose Crisis and Fentanyl: The Role of Online Information Seeking via Internet Search Engines

A Fatal Case of Poisoning with Fentanyl Transdermal Patches in Japan

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