Abuse victimization and risk of breast cancer in the Black Women’s Health Study

Wise, Lauren A.; Palmer, Julie R.; Boggs, Deborah A.; Adams‐Campbell, Lucile L.; Rosenberg, Lynn

doi:10.1007/s10552-011-9738-3

Cited by 22 publications

(24 citation statements)

References 71 publications

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“…Summary effect estimates were not computed due to heterogeneity across studies. Of the 12 studies, 7 were conducted in the United States, 2,15–20 2 were conducted in Great Britain, 21,22 1 in Canada, 23 1 in Finland, 24 and 1 in Saudi Arabia. 25 Six of the studies used a cross-sectional study design, 17–20,22,23 collecting data on both ACEs and previous cancer diagnosis at the same point in time.…”

Section: Resultsmentioning

confidence: 99%

The Association Between Adverse Childhood Experiences and Risk of Cancer in Adulthood: A Systematic Review of the Literature

Holman¹,

Ports

Buchanan³

et al. 2016

Pediatrics

170

116

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CONTEXT Adverse childhood experiences (ACEs) can affect health and well-being across the life course. OBJECTIVE This systematic review summarizes the literature on associations between ACEs and risk of cancer in adulthood. DATA SOURCES We searched PubMed to identify relevant publications published on or before May 31, 2015. STUDY SELECTION We included original research quantifying the association between ACEs and adult cancer incidence. Case reports and reviews were excluded. DATA ABSTRACTION Two reviewers independently abstracted and summarized key information (eg, ACE type, cancer type, risk estimates) from included studies and resolved all discrepancies. RESULTS Twelve studies were included in the review. In studies in which ACE summary scores were calculated, significant associations were observed between the scores and an increased risk of cancer in adulthood. Of the different types of ACEs examined, physical and psychological abuse victimization were associated with risk of any cancer in 3 and 2 studies, respectively. Two studies also reported significant associations with regard to sexual abuse victimization (1 for cervical cancer and 1 for any cancer). However, 2 other studies reported no significant associations between childhood sexual or physical abuse and incidence of cervical or breast cancer. LIMITATIONS Because of heterogeneity across studies, we were unable to compute a summary effect estimate. CONCLUSIONS These findings suggest that childhood adversity in various forms may increase a person’s cancer risk. Further research is needed to understand the mechanisms driving this relationship and to identify opportunities to prevent and mitigate the deleterious effects of early adversity on long-term health.

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Section: Resultsmentioning

confidence: 99%

The Association Between Adverse Childhood Experiences and Risk of Cancer in Adulthood: A Systematic Review of the Literature

Holman¹,

Ports

Buchanan³

et al. 2016

Pediatrics

170

116

View full text Add to dashboard Cite

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“…Finally, within each life stage, we created a “severity” variable that defined “mild” abuse as one type of physical abuse that occurred ≥4 times; “moderate” abuse as sexual abuse 1–3 times and/or two forms of physical abuse occurring ≥4 times or a more severe form of physical abuse (burn or choke or seriously harm someone I love) occurring at any frequency; “severe” abuse as 3 or more types of physical abuse occurring ≥4 times and/or sexual abuse ≥4 times; and “very severe” abuse includes 3 or more types of physical abuse occurring ≥4 times and sexual abuse ≥4 times. These abuse definitions have been used in previous publications from the BWHS 48–50 and other studies. 51,52 …”

Section: Methodsmentioning

confidence: 99%

Lifetime abuse victimization and risk of uterine leiomyomata in black women

Wise

Palmer

Rosenberg

2013

American Journal of Obstetrics and Gynecology

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Objective Uterine leiomyomata (UL) are a major contributor to gynecologic morbidity and medical costs, and black women are disproportionately affected by the condition. Previous studies have linked UL to psychosocial stress, including child abuse. We assessed the association between lifetime abuse victimization and UL among 9,910 premenopausal women. Study Design Data were derived from the Black Women’s Health Study, a prospective cohort study. In 2005, participants reported their experiences of physical and sexual abuse within each life stage (childhood, adolescence, adulthood). Biennial follow-up questionnaires from 2005 through 2011 ascertained new UL diagnoses. Rate ratios (RR) and 95% confidence intervals (CI) were estimated using Cox regression. Results There were 1,506 incident UL cases diagnosed by ultrasound or surgery. UL incidence was higher among women who reported child abuse, particularly sexual abuse. Relative to no abuse across the lifespan, RRs were 1.16 (CI, 1.02–1.33) for physical abuse only, 1.34 (CI, 1.09–1.66) for sexual abuse only, and 1.17 (CI, 0.99–1.39) for both physical and sexual abuse in childhood. RRs for 1–3 and ≥4 incidents of child sexual abuse were 1.29 (CI, 1.04–1.61) and 1.41 (CI, 1.07–1.85), respectively, while RRs for low, intermediate, and high frequencies of child physical abuse were 1.19, 1.04, and 1.23, respectively. The association was strongest for the highest category of child abuse severity (RR=1.57, CI, 1.19–2.07). No associations were found for teen or adult abuse. Conclusions In the present study, child sexual abuse was an independent risk factor for UL, supporting the hypothesis that childhood adversity increases UL risk.

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“…Finally, we created a 'severity' variable that defined 'mild' abuse as one type of physical abuse that occurred more than or equal to four-times or a more severe form of physical abuse (burn or choke or seriously harm someone I love) occurring one to threetimes; 'moderate' abuse as sexual abuse one to threetimes and/or two forms of physical abuse occurring more than or equal to four-times or a more severe form of physical abuse (burn or choke or seriously harm someone I love) occurring at any frequency; 'severe' abuse as three or more types of physical abuse occurring more than or equal to four-times and/or sexual abuse more than or equal to four-times; and 'very severe' abuse includes three or more types of physical abuse occurring more than or equal to four-times and sexual abuse more than or equal to four-times. These abuse definitions have been used in previous publications from the BWHS [24,[27][28][29][30] and other studies [31,32].…”

Section: Future Science Groupmentioning

confidence: 99%

Childhood Abuse, Promoter Methylation of Leukocyte NR3C1 and the Potential Modifying Effect of Emotional Support

et al. 2016

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Aim:To investigate childhood abuse victimization in relation to adult DNA methylation levels in a novel region of NR3C1, with emotional support as a possible modifier. Materials & methods: 295 participants from the Black Women's Health Study. Multivariable linear regression models were used to compute differences in mean percent methylation levels. Results: Women reporting childhood abuse victimization exhibited higher mean NR3C1 methylation levels than nonabused women, with a clear dose-response relationship. Childhood emotional support appeared to attenuate associations only among women with the highest levels of physical and sexual abuse. Conclusion: NR3C1 mean methylation was higher among women who reported childhood abuse. Further research is warranted to clarify whether or the extent to which childhood emotional support buffers the association.

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Abuse victimization and risk of breast cancer in the Black Women’s Health Study

Cited by 22 publications

References 71 publications

The Association Between Adverse Childhood Experiences and Risk of Cancer in Adulthood: A Systematic Review of the Literature

The Association Between Adverse Childhood Experiences and Risk of Cancer in Adulthood: A Systematic Review of the Literature

Lifetime abuse victimization and risk of uterine leiomyomata in black women

Childhood Abuse, Promoter Methylation of Leukocyte NR3C1 and the Potential Modifying Effect of Emotional Support

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