ABX464 (obefazimod) for patients with COVID-19 at risk for severe disease: miR-AGE, a randomized, double-blind placebo-controlled trial

Giavina-Bianchi, Pedro; Cua, Eric; Risso, Karine; Mondain, Véronique; Vissian, Anaïs; Joie, Cécile; Pouletty, Philippe; Gineste, Paul; Ehrlich, Hartmut J.; Kalil, Jorge

doi:10.1016/j.jacig.2023.100140

Cited by 2 publications

(1 citation statement)

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“…Obefazimod (ABX464) is a small molecule that up-regulates miR-124 in immune cells that reduces the production of inflammatory cytokines and prevents the proliferation of Th17 cells. However, once-daily oral obefazimod in a dose of 50 mg provided no benefit over placebo for severe COVID-19 in a randomized, double-blind placebo-controlled trial (miR-AGE) [66].…”

Section: Role Of Mirnas In Anti-infectious Immunitymentioning

confidence: 99%

Role of microRNAs in Immune Regulation with Translational and Clinical Applications

Gaál

2024

IJMS

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MicroRNAs (miRNAs) are 19–23 nucleotide long, evolutionarily conserved noncoding RNA molecules that regulate gene expression at the post-transcriptional level. In this review, involvement of miRNAs is summarized in the differentiation and function of immune cells, in anti-infective immune responses, immunodeficiencies and autoimmune diseases. Roles of miRNAs in anticancer immunity and in the transplantation of solid organs and hematopoietic stem cells are also discussed. Major focus is put on the translational clinical applications of miRNAs, including the establishment of noninvasive biomarkers for differential diagnosis and prediction of prognosis. Patient selection and response prediction to biological therapy is one of the most promising fields of application. Replacement or inhibition of miRNAs has enormous therapeutic potential, with constantly expanding possibilities. Although important challenges still await solutions, evaluation of miRNA fingerprints may contribute to an increasingly personalized management of immune dysregulation with a remarkable reduction in toxicity and treatment side effects. More detailed knowledge of the molecular effects of physical exercise and nutrition on the immune system may facilitate self-tailored lifestyle recommendations and advances in prevention.

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Section: Role Of Mirnas In Anti-infectious Immunitymentioning

confidence: 99%