Acacetin antagonized lipotoxicity in pancreatic β-cells via ameliorating oxidative stress and endoplasmic reticulum stress

Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids

“…Other dietary flavonoids, including their oxidation and polymerization products such as tectorigenin, acacetin, liquiritigenin, and 7,8-hydroxyflavone have cytoprotective effects on β-cells’ ER stress ( Bae et al, 2018 ; Sahin et al, 2022 ; Wang et al, 2022 ; Yao et al, 2020 ). Tectorigenin, a methoxyisoflavone found in many plants has various pharmacological activities such as antidiabetic, antimutagenic, estrogenic, hypolipidemic, anti-tumor, hepatoprotective, anticarcinogenic anti-inflammatory, and antioxidant properties ( Han et al, 2012 ).…”

“…Acacetin is suggested to have cytoprotective effects on β-cells ER stress by its antioxidant and anti-inflammatory effects and by promoting AMPK phosphorylation ( Song et al, 2022 ). Acacetin alleviates lipotoxicity and relieves ER stress-mediated cell apoptosis in pancreatic cells by upregulating the endogenous antioxidant enzymes and downregulating CHOP expression ( Wang et al, 2022 ), suggesting a beneficial role in preventing β-cells dysfunction and loss in diabetes and obesity. Similarly, the acacetin analog, 7,8-Dihydroxyflavone improved metabolic abnormalities, inflammation, and ER stress in vivo by downregulating GRP78 and CHOP expression ( Sahin et al, 2022 ).…”