Acacia seyal and Terminalia brownii associated airborne contact dermatitis (Dukhan dermatitis)

Öztürk, Melike Kibar; Zindancı, İlkin; Zemheri, Ebru

doi:10.1111/ijd.14194

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Terminalia brownii Fresen. has been used to treat brown-erythematous excoriated papules, plaques, and lichenification in the formulation of scented smoke baths ( Kibar Ozturk et al., 2018 ). In traditional medicine in Southeast Asia, the aqueous extract of Terminalia catappa L. leaves are used to treat antipyretic, hemostatic, hepatitis, and liver-related diseases T. catappa L. is also used to manage diabetic due to its property of reducing oxidative stress, inflammation, angiogenesis, lipid profile correction, and direct hypoglycemic actions ( Behl and Kotwani, 2017 ).…”

Section: Terminalia Sp Medicinal Potential (Folk Medicinal mentioning

confidence: 99%

“…is traditionally used for cardioprotective and hepatoprotective purposes in India and Sri Lanka ( Kapoor et al., 2014 ); T. bellirica (Gaertn.) Roxb., is widely used on treating diarrhea ( Pandey et al., 2017 ); Terminalia brownii Fresen., has been used to treat brown-erythematous excoriated papules and plaques ( Kibar Ozturk et al., 2018 ); T. chebula Retz. is widely used to treat dementia, constipation, and diabetes in traditional Indian and Iranian medicine ( Jokar et al., 2016 ), etc.…”

Section: Introductionmentioning

confidence: 99%

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Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies

et al. 2020

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The evaluation and confirmation of healing properties of several plant species of genus Terminalia based on their traditional uses and the clinical claims are of utmost importance. Genus Terminalia has received more attention to assess and validate the therapeutic potential and clinical approval due to its immense folk medicinal and traditional applications. Various species of Terminalia genus are used in the form of herbal medicine and formulations, in treatment of diseases, including headache, fever, pneumonia, flu, geriatric, cancer, to improve memory, abdominal and back pain, cough and cold, conjunctivitis, diarrhea, heart disorder, leprosy, sexually transmitted diseases, and urinary tract disorders. These are reported to possess numerous biological properties, counting: antibacterial, antifungal, antiinflammatory, antiviral, antiretroviral, antioxidant, and antipa7rasitic. This current research review aims to update the detailed biological activities, pre-clinical and clinical studies of various extracts and secondary metabolites from several plant species under the genus Terminalia , along with information on the traditional uses and chemical composition to develop a promising strategy for their potential applications in the form of medicine or use in modern drug formulations for treating diseases like pneumonia, flu, and other types of viral infections or controlling human contagions.

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Section: Terminalia Sp Medicinal Potential (Folk Medicinal mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies

et al. 2020

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Ocular allergic contact dermatitis from topical drugs

Erdinest

Nche

London

et al. 2020

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewOcular allergic contact dermatitis is a common yet challenging and frequently misdiagnosed condition. Inappropriate or delayed treatment can contribute to a variety of clinical symptoms such as tearing and itching with signs such as ptosis and cicatricial ectropion, resulting in deterioration of disease, for which the topical medication was originally prescribed to resolve.Recent findingsUnderstanding previously unrecognized pathogenic mechanisms involving ocular contact dermatitis has driven new approaches to control the inflammatory process by neutralizing inflammatory mediators and their receptors.SummaryEarly diagnosis and removing the antagonizing substance is crucial to manage ocular contact dermatitis. Steroid therapy is usually required to reduce symptoms. As ocular allergic dermatitis often develops in patients using drugs for chronic conditions that necessitate chronic application, it may be difficult at times to discontinue or replace the offending agent.

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Protein Expression Profiling and Virtual Drug Screening as an Approach for Individualized Therapy of Small Cell Vaginal Carcinoma

Saeed

Khalid

Thakur³

et al. 2022

Cancer Genomics Proteomics

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Background: Small cell vaginal carcinoma is a very rare gynecological cancer and treatments including chemo-and radiotherapy have had limited success. Case Report: We report the case of a 37-year-old female, where intensive treatment with the combination of paclitaxel, carboplatin, irinotecan, and camptothecin with and without irradiation did not avoid metastasis of the tumor and the death of the patient. In an attempt to develop a strategy for individualized tumor therapy, we performed immunohistochemistry of 19 cancer-related proteins using a biopsy sample. Strong expression was observed for glutathione S-transferase P1 (GSTP1), epidermal growth factor receptor (EGFR), inducible nitric oxide synthetase (iNOS), nuclear factor kappa B (NF-ĸB), the oncogene c-MYC, vascular endothelial growth factor (VEGF), and the proliferation marker Ki-67. Intermediate expression was found for the oncogene SRC, β-catenin, and the viral E7 protein. We then performed virtual drug screening with PyRx and molecular docking with AutoDock 4.2.6 by using the three-dimensional structures of these proteins and a chemical library of 1,577 FDA-approved drugs, in a drug repurposing approach. The top 15 compounds were either approved anticancer drugs or drugs used to treat nonmalignant diseases. These compounds were bound with comparable or even higher affinity to the targets compared to control inhibitors. Several of these compounds were bound with high affinity to more than one of these target proteins, further supporting the drug repurposing concept. Conclusion: These drugs might offer additional opportunities to reach treatment responses. This approach of individualized tumor therapy might be theoretically not only applicable for small cell vaginal carcinoma but for other tumor entities as well.

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Acacia seyal and Terminalia brownii associated airborne contact dermatitis (Dukhan dermatitis)

Cited by 3 publications

References 21 publications

Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies

Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies

Ocular allergic contact dermatitis from topical drugs

Protein Expression Profiling and Virtual Drug Screening as an Approach for Individualized Therapy of Small Cell Vaginal Carcinoma

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