ObjectiveLiver transplant recipients are at a high risk of infection during the first month. Therefore, it is crucial to implement isolation measures correctly to prevent the spread of nosocomial infections. Evidence‐based practices and proper implementation of isolation measures can significantly reduce morbidity and mortality. The study aimed to investigate the impact of nurses' attitudes towards evidence‐based nursing on their compliance with isolation measures.MethodsThis is a descriptive study conducted between October 2023 and January 2024, with the participation of 137 nurses working in the organ transplant clinics of a university hospital in Turkey. Data was collected using a participant introduction form, the attitudes towards evidence‐based nursing scale, and the compliance with isolation measures scale.ResultsThe mean total score for the scale of attitudes towards evidence‐based nursing among nurses was 55.95 ± 10.43 (15–75). Similarly, the mean total score for the scale of compliance with isolation measures was 71.44 ± 13.53 (18–90). Both scores were above the middle level. The study found a moderately significant positive correlation between attitudes towards evidence‐based nursing and compliance with isolation measures (r: 0.670, p: 0.000). The regression model showed that the attitude towards evidence‐based nursing explained 44.9% of the positivity towards isolation measures (R2 = 0.449).ConclusionsThe study found a positive correlation between nurses' positive attitudes towards evidence‐based nursing and their compliance with isolation precautions when caring for liver transplant patients. This highlights the significance of evidence‐based nursing in patient care and the importance of adhering to isolation measures to prevent nosocomial infections.