Nowadays researchers are paying more attention to factors that may lead to the promotion or inhibition of the academic performance and socializing the education through fostering the academic support. Cognitive abilities are no longer sufficient to determine academic success or failure, it is important to investigate the psychological skills as locus of control. The study aimed to investigate nursing student's experience on locus of control and its relation with learning performance and academic support. Cross section analytical study design was used to fulfill this study. This study was conducted at two settings: Faculty of Nursing, Mansoura University and Faculty of Nursing, Suez Canal University. The study sample includes 222 students from Mansoura University and 186 students from Suez Canal University. Data of the present study were collected by using three tools namely: Internal-External Locus of Control Scale, Learning Performance Scale and perceived academic support scale. Results of the present study indicated that more than half of students had internal locus of control rather than external locus of control, 55.9% of students had internal locus of control in Suez Canal University and 59.5% in Mansoura University, high learning performance and high perceived academic support of the participated students. There was no significant correlation between locus of control (internal or external) and learning performance or perceived academic support. more than half of students had internal locus of control rather than external locus of control and there was no significant correlation between locus of control (internal or external) and learning performance or perceived academic support. According to study findings academic administrators should pay attention to help students to improve and understand how their self perceptions may affect their academic performance.