Academic stress, social support, and secretory immunoglobulin A.

Jemmott, John B.; Magloire, Kim

doi:10.1037/0022-3514.55.5.803

Cited by 151 publications

(88 citation statements)

References 49 publications

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“…Consequently, an initial negative impact on the animal's well-being is to be expected after surgery. A transient reduction of food intake and BW loss as described for humans (Jemmott & Magloire 1988) was thus to be expected in the rats of the present study. Considering that the rats employed in our study were young and growing, the effect on BW gain was obvious.…”

Section: Discussionmentioning

confidence: 98%

Impact of chronic catheterization and automated blood sampling (Accusampler) on serum corticosterone and fecal immunoreactive corticosterone metabolites and immunoglobulin A in male rats

Royo¹,

Bjork²,

Carlsson³

et al. 2004

Journal of Endocrinology

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Jugular catheters were inserted in nine male rats under general isofluorane anesthesia and the catheters were connected to a commercially available computerized blood sampling device (Accusampler). Blood samples (150 µl) were collected every 4 h during the first 24 h after surgery and every 12 h during the following 72 h until 94 h after surgery, when the animals were killed. All fecal pellets were collected at blood sampling. Serum corticosterone and fecal concentrations of immunoreactive corticosterone metabolites and immunoglobulin A (IgA) were quantified by ELISAs. In blood, high corticosterone concentrations (.200 ng/ml) were recorded in the first samples obtained after surgery, but the concentrations decreased steadily during the day and became cyclical, showing a diurnal variation with high levels during evenings and low levels in the mornings. The automatic blood sampling itself did not result in recordable increases in serum corticosterone concentrations. The time delay between the presence of elevated corticosterone levels in blood and in feces was approximately 12 h. Fecal immunoreactive corticosterone metabolite levels remained elevated during the 94 h study period after surgery. The fecal concentrations of IgA showed substantial between-animal variation and decreased non-significantly after the surgery. Like serum corticosterone, fecal IgA showed a diurnal variation in amounts excreted, in this case with high values in the morning and low values in the evening. The concentrations of fecal corticosterone and IgA were negatively correlated in samples obtained before surgery but no correlation existed after surgery. This indicates that fecal immunoreactive corticosterone metabolites, but not IgA, constitute a good marker of acute stress. For immunoreactive corticosterone metabolites as well as for IgA, the concentration in feces correlated well with total excretion, making single fecal samplings usable as a measure of total secretion.

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Section: Discussionmentioning

confidence: 98%

Impact of chronic catheterization and automated blood sampling (Accusampler) on serum corticosterone and fecal immunoreactive corticosterone metabolites and immunoglobulin A in male rats

Royo¹,

Bjork²,

Carlsson³

et al. 2004

Journal of Endocrinology

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“…Modification of s-IgA synthesis could play a greater role in the changes in s-IgA secretion observed in response to long term intensive training and chronic psychological stress (99)(100)(101). In addition, it may be that repeated mobilisation of the pIgR could deplete the available formed IgA pool, leading to decreases in s-IgA output.…”

Section: Possible Mechanismsmentioning

confidence: 99%

Acute and chronic effects of exercise on markers of mucosal immunity

Nicolette¹

2009

Front Biosci

186

146

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Decreased secretion rate of salivary markers of mucosal immunity, and in particular salivary immunoglobulin A (sIgA), have been implicated as risk factors for subsequent episodes of respiratory infection in athletes. IgA is the predominant Ig in mucosal secretions and acts with innate mucosal defences to provide the 'first line of defence' against pathogens and antigens presented at the mucosa. As well as summarising the evidence concerning the effects of acute exercise and longer-term intensive training on these markers of mucosal immunity, this review explores the factors that impact upon salivary responses to exercise, such as method of saliva collection, stimulation of saliva collection and the method of reporting s-IgA data. The influence of adequate hydration and nutritional supplementation during exercise as well as exercising in extreme environmental conditions on salivary responses is also explored. Finally, the possible mechanisms underlying the acute and longer-term of effects of exercise on salivary responses are examined, with particular emphasis on the potential role of the sympathetic nervous system and the expression and mobilisation of the polymeric Ig receptor. INTRODUCTIONOver the past two decades a growing body of evidence has supported the notion that both acute, strenuous exercise and intensive periods of physical training are associated with immune suppression and this may be linked to the apparent higher incidence of upper respiratory tract infections (URTI) in highly conditioned athletes (1,2). The acute decrease in immune function is transient and is dependent on the exercise intensity and duration. Repeated activity with insufficient recovery, such as during heavy periods of training and competition, appears to exacerbate the situation leading to a chronic depression of several aspects of immune function (3)(4)(5). Although the majority of studies have concentrated on continuous endurance-type activities such as distance running, cycling and swimming, evidence to support the concept of an exercise-induced immune depression has also been found following high-intensity intermittent activities such as football and tennis as well as high intensity resistance exercise (6-8).In contrast to the effects of intensive exercise on immune function, moderate amounts of physical activity in previously sedentary individuals, such as 30 min of brisk walking on most days of the week, are associated with either little effect on (9,10) or elevations (11,12) of markers of immunity and such activity has been associated with a lower incidence of URTI compared with sedentary individuals (1,9,11). The relationship between the amount of exercise and incidence of URTI has been proposed by Nieman (13) as a J-shaped curve and is largely supported by epidemiological data (9,11,14,15). However, identifying a definitive link between prevalence of URTI and any exercise-induced alterations in cellular and mucosal immunity has proved more difficult, not least because of the many confounders that could influence...

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“…People experiencing periods of chronic stress have been shown reductions in the number of helper T-lymphocytes [11][12][13], B-lymphocytes [14], and salivary concentrations of secretory immunoglobulin A (sIgA) [15][16][17][18], compared to controls. The clinical implications of reductions in these cell counts in healthy people, and within normal ranges, are unclear [19].…”

Section: Introductionmentioning

confidence: 99%

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Burns

Carroll

Ring

et al. 2003

Vaccine

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The purpose of this review is to determine the effects of psychosocial stress on antibody response to vaccination in humans, consider possible mechanisms, and identify agenda for future research. Studies of the association between stress and vaccination response in humans were reviewed. There is evidence of a negative association between stress and antibody response to vaccination, which is most apparent with thymusdependent vaccines and when measured at extended times after vaccination. Preliminary findings implicate the hypothalamic-pituitary-adrenal axis and sympathetic nervous system as potential mechanisms, although a role for unhealthy behaviours cannot be discounted at this stage. Results to date are sufficiently indicative to direct future research to untangling their theoretical ramifications, as well as realising their clinical implications.

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Academic stress, social support, and secretory immunoglobulin A.

Cited by 151 publications

References 49 publications

Impact of chronic catheterization and automated blood sampling (Accusampler) on serum corticosterone and fecal immunoreactive corticosterone metabolites and immunoglobulin A in male rats

Impact of chronic catheterization and automated blood sampling (Accusampler) on serum corticosterone and fecal immunoreactive corticosterone metabolites and immunoglobulin A in male rats

Acute and chronic effects of exercise on markers of mucosal immunity

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

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