Academic stress, depression, and anxiety are major issues among adolescents attending schools in China and other Asian countries. Many studies have argued that academic stress is associated with depression and anxiety symptoms. However, limited studies have investigated these variables across the full adolescent age group (10 to 19 years). In addition, given the fact that non-Shenzhen residents constitute a large proportion of the Shenzhen population, it would be worthwhile to investigate the potential moderating effects of residency type over academic stress, depression and anxiety amongst this population.The present study aimed to identify the relationship between academic stress and depression and anxiety symptoms among adolescents in Shenzhen, China. Another objective was to investigate the significant demographic factors that could affect academic stress, depression, and anxiety symptoms. Thirdly, the study aimed to the moderating effects of gender and residency type on adolescents' academic stress, depression and anxiety.In terms of the linear regression analyses, academic stress, depression, and anxiety were the dependent variables. Regarding academic stress, studying in higher grade levels, having poorer academic achievement, and less amount of pocket money were found to be the risk factors for academic stress. For depression symptoms, being female, fewer years living in Shenzhen, poor academic performance, high levels of academic stress, higher grade levels, not living in own accommodation and coming from disrupted families were found to be the risk factors. In regards to anxiety symptoms, being female, high levels of academic stress and being in higher grade levels were the risk factors.Academic stress was consistently the strongest risk factor for depressive and anxious symptoms in adolescents from Shenzhen China. This finding emphasises the importance of the Academic stress and mental health among adolescents in Shenzhen, China v need to develop effective interventions to reduce academic stress in Chinese adolescents.Gender and grade level were significant factors for all the three variables -academic stress, depression, and anxiety symptoms. These findings could be used to guide professionals, such as teachers and psychologists, to implement specific plans for adolescents. In addition, future studies are recommended to continue to investigate the impact of demographic moderators upon the mental health issues of Chinese adolescents.