Açaí (Euterpe oleracea Mart.) Seed Oil Exerts a Cytotoxic Role over Colorectal Cancer Cells: Insights of Annexin A2 Regulation and Molecular Modeling

Silva, Marcos Antônio Custódio Neto da; Tessmann, Josiane Weber; Borges, Kátia Regina Assunção; Wolff, Laís Araújo Souza; Botelho, Fernanda D.; Vieira, Leandro A.; Morgado‐Díaz, José Andrés; França, Tanos C. C.; Barbosa, Maria do Carmo Lacerda; Nascimento, Maria do Desterro Soares Brandão; Rocha, Murilo Ramos; Carvalho, João Ernesto de

doi:10.3390/metabo13070789

Cited by 5 publications

(2 citation statements)

References 88 publications

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“…Silva et al [ 49 ] aimed to analyze the effects of açai seed extract and oil ( Euterpe oleracea Mart.) on different human colon adenocarcinoma cell lines (Caco-2, HT-29, and HCT-116).…”

Section: Biological Effects Of Fruits Of Amazonian Palm Treesmentioning

confidence: 99%

Amazonian palm tree fruits: From nutritional value to diversity of new food products

Amorim,

Godoy

et al. 2024

Heliyon

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“…Silva et al [ 49 ] aimed to analyze the effects of açai seed extract and oil ( Euterpe oleracea Mart.) on different human colon adenocarcinoma cell lines (Caco-2, HT-29, and HCT-116).…”

Section: Biological Effects Of Fruits Of Amazonian Palm Treesmentioning

confidence: 99%

Amazonian palm tree fruits: From nutritional value to diversity of new food products

Amorim,

Godoy

et al. 2024

Heliyon

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“…Monge-Fuentes et al (2017) demonstrated that açaí oil inhibited cell viability in B16F10 murine melanoma cell lines by 85% through apoptosis [9]. Similarly, Da showed that both the extract and the seed oil exhibited cytotoxic effects on colorectal adenocarcinoma cell lines CACO-2, HCT-116, and HT-29 [22].…”

Section: Introductionmentioning

confidence: 99%

Açaí (Euterpe oleracea Mart.) Seed Oil and Its Nanoemulsion: Chemical Characterisation, Toxicity Evaluation, Antioxidant and Anticancer Activities

Borges,

Wolff,

da Silva

et al. 2024

CIMB

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This study explores a nanoemulsion formulated with açaí seed oil, known for its rich fatty acid composition and diverse biological activities. This study aimed to characterise a nanoemulsion formulated with açaí seed oil and explore its cytotoxic effects on HeLa and SiHa cervical cancer cell lines, alongside assessing its antioxidant and toxicity properties both in vitro and in vivo. Extracted from fruits sourced in Brazil, the oil underwent thorough chemical characterization using gas chromatography–mass spectrometry. The resulting nanoemulsion was prepared and evaluated for stability, particle size, and antioxidant properties. The nanoemulsion exhibited translucency, fluidity, and stability post centrifugation and temperature tests, with a droplet size of 238.37, PDI -9.59, pH 7, and turbidity 0.267. In vitro assessments on cervical cancer cell lines revealed antitumour effects, including inhibition of cell proliferation, migration, and colony formation. Toxicity tests conducted in cell cultures and female Swiss mice demonstrated no adverse effects of both açaí seed oil and nanoemulsion. Overall, açaí seed oil, particularly when formulated into a nanoemulsion, presents potential for cancer treatment due to its bioactive properties and safety profile.

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Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach

Al Azzani,

Nizami,

Magramane

et al. 2024

Phytotherapy Research

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Autophagy and endoplasmic reticulum (ER) stress are conserved processes that generally promote survival, but can induce cell death when physiological thresholds are crossed. The pro‐survival aspects of these processes are exploited by cancer cells for tumor development and progression. Therefore, anticancer drugs targeting autophagy or ER stress to induce cell death and/or block the pro‐survival aspects are being investigated extensively. Consistently, several phytochemicals have been reported to exert their anticancer effects by modulating autophagy and/or ER stress. Various phytochemicals (e.g., celastrol, curcumin, emodin, resveratrol, among others) activate the unfolded protein response to induce ER stress‐mediated apoptosis through different pathways. Similarly, various phytochemicals induce autophagy through different mechanisms (namely mechanistic target of Rapamycin [mTOR] inhibition). However, phytochemical‐induced autophagy can function either as a cytoprotective mechanism or as programmed cell death type II. Interestingly, at times, the same phytochemical (e.g., 6‐gingerol, emodin, shikonin, among others) can induce cytoprotective autophagy or programmed cell death type II depending on cellular contexts, such as cancer type. Although there is well‐documented mechanistic interplay between autophagy and ER stress, only a one‐way modulation was noted with some phytochemicals (carnosol, capsaicin, cryptotanshinone, guangsangon E, kaempferol, and δ‐tocotrienol): ER stress‐dependent autophagy. Plant extracts are sources of potent phytochemicals and while numerous phytochemicals have been investigated in preclinical and clinical studies, the search for novel phytochemicals with anticancer effects is ongoing from plant extracts used in traditional medicine (e.g., Origanum majorana). Nonetheless, the clinical translation of phytochemicals, a promising avenue for cancer therapeutics, is hindered by several limitations that need to be addressed in future studies.

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Açaí (Euterpe oleracea Mart.) Seed Oil Exerts a Cytotoxic Role over Colorectal Cancer Cells: Insights of Annexin A2 Regulation and Molecular Modeling

Cited by 5 publications

References 88 publications

Amazonian palm tree fruits: From nutritional value to diversity of new food products

Amazonian palm tree fruits: From nutritional value to diversity of new food products

Açaí (Euterpe oleracea Mart.) Seed Oil and Its Nanoemulsion: Chemical Characterisation, Toxicity Evaluation, Antioxidant and Anticancer Activities

Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach

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