Açai Improves Non-Alcoholic Fatty Liver Disease (Nafld) Induced by Fructose

Carvalho, Mayara Medeiros de Freitas; Reis, Larissa Lélis Teixeira; Lopes, Juliana Márcia Macedo; Lage, Nara Nunes; Guerra, Joyce Ferreira da Costa; Zago, Helena Porto; Bonomo, L; Pereira, Renata Rebeca; Lima, Wanderson Geraldo de; Silva, Marcelo Eustáquio; Pedrosa, Maria Lúcia

doi:10.20960/nh.1294

Cited by 6 publications

(1 citation statement)

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“…Our results are in agreement with those recently published by de Freitas Carvalho and collaborators [30], who found a significant decrease of fat accumulation induced by açai extract both on in vitro and in vivo models. Further in vivo studies are necessary to establish a dose/response correlation, however also the specific application, in functional food, of food supplement or even cosmeceutical formulation (topical use), is relevant to assess the optimal active concentration.…”

Section: Discussionsupporting

confidence: 94%

Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food

et al. 2020

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Several plant extracts are acquiring increasing value because of their antioxidant activity and hypolipidemic properties. Among them, great interest has been recently paid to açai fruit as a functional food. The aim of this study was to test the ability of açai extract in reducing oxidative stress and modulating lipid metabolism in vitro using different cell models and different types of stress. In fact, lipid peroxidation as evaluated in a HepG2 model was reduced five-fold when using 0.25 µg/mL of extract, and it was further reduced (20-fold) with the concentration increase up to 2.5 µg/mL. With the nonalcoholic fatty liver disease (NAFLD)in vitro model, all concentrations tested showed at least a two-fold reduced fat deposit. In addition, primary adipocytes challenged with TNF-α under hypoxic conditions to mimic the persistent subcutaneous fat, treated with açai extract showed an approximately 40% reduction of fat deposit. Overall, our results show that açai is able to counteract oxidative states in all the cell models analysed and to prevent the accumulation of lipid droplets. No toxic effects and high stability overtime were highlighted at the concentrations tested. Therefore, açai can be considered a suitable support in the prevention of different alterations of lipid and oxidative metabolism responsible for fat deposition and metabolic pathological conditions.

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Section: Discussionsupporting

confidence: 94%

Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food

et al. 2020

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Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review

Svobodová,

Horní,

Velecká

et al. 2024

Arch Toxicol

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Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition characterized by liver steatosis, inflammation, consequent fibrosis, and cirrhosis. Chronic impairment of lipid metabolism is closely related to oxidative stress, leading to cellular lipotoxicity, mitochondrial dysfunction, and endoplasmic reticulum stress. The detrimental effect of oxidative stress is usually accompanied by changes in antioxidant defense mechanisms, with the alterations in antioxidant enzymes expression/activities during MASLD development and progression reported in many clinical and experimental studies. This review will provide a comprehensive overview of the present research on MASLD-induced changes in the catalytic activity and expression of the main antioxidant enzymes (superoxide dismutases, catalase, glutathione peroxidases, glutathione S-transferases, glutathione reductase, NAD(P)H:quinone oxidoreductase) and in the level of non-enzymatic antioxidant glutathione. Furthermore, an overview of the therapeutic effects of vitamin E on antioxidant enzymes during the progression of MASLD will be presented. Generally, at the beginning of MASLD development, the expression/activity of antioxidant enzymes usually increases to protect organisms against the increased production of reactive oxygen species. However, in advanced stage of MASLD, the expression/activity of several antioxidants generally decreases due to damage to hepatic and extrahepatic cells, which further exacerbates the damage. Although the results obtained in patients, in various experimental animal or cell models have been inconsistent, taken together the importance of antioxidant enzymes in MASLD development and progression has been clearly shown.

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Combined action of açai and aerobic exercise training on the development of NAFLD induced by a high-fat diet: a preliminary exploration

et al. 2021

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Açai Improves Non-Alcoholic Fatty Liver Disease (Nafld) Induced by Fructose

Abstract: the replacement of starch by fructose during this period was effective in promoting NAFLD. Açai showed attenuating effects on some markers of hepatic steatosis and inflammation.

Cited by 6 publications

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Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food

Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food

Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review

Combined action of açai and aerobic exercise training on the development of NAFLD induced by a high-fat diet: a preliminary exploration

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