Acalculous Cholecystitis Secondary to Hepatitis C Infection

et al. 2023

Preprint

Background: This study aimed to understand the incidence and clinical significance of acalculous cholecystitis in patients with acute hepatitis E (HE). Patients and methods: A single center enrolled 114 patients with acute HE. All patients underwent imaging of the gallbladder, and patients with gallstones and cholecystectomy were excluded. Results: Acalculous cholecystitis was found in 66 patients (57.89%) with acute HE. The incidence in males was 63.95%, which was significantly higher than in females (39.29%) (P=0.022). The mean length of hospital stay and the incidence of spontaneous peritonitis in patients with cholecystitis (20.12 ± 9.43 days and 9.09%, respectively) were significantly higher than those in patients without cholecystitis (12.98 ± 7.26 days and 0%, respectively) (P<0.001 and P=0.032). Albumin , total bile acid, bilirubin, cholinesterase, and prothrombin activity in patients with cholecystitis were significantly inferior to those in patients without cholecystitis (P<0.001, P<0.001, P<0.001, P<0.001 and P= 0.003, respectively). After correction by multivariate analysis, albumin and total bile acid were found to be closely related to acalculous cholecystitis in HE. Conclusion: Acalculous cholecystitis is very common in patients with acute HE, and may serve as a predictor of increased peritonitis, synthetic decompensation, and longer hospital stay.

Section: Introductionmentioning

confidence: 99%

Acalculous cholecystitis is a common extrahepatic manifestation of hepatitis E and suggests a more serious condition

et al. 2023

Preprint

“…Acalculous cholecystitis can occur in conjunction with multiple organ failure, and its occurrence often indicates multisystemic failure [ 11 ]. Although it was reported in 1987 that acalculous cholecystitis may be an extrahepatic complication of liver disease [ 12 ], viral hepatitis-related acalculous cholecystitis is mostly reported in relation to hepatitis A virus (HAV) [ 13 – 20 ] with few reports in hepatitis B virus (HBV) [ 21 ] and C [ 22 – 24 ]. Metabolites of the virus may invade the wall of the gallbladder or biliary epithelial cells, leading to cholestasis, which in turn results in acalculous cholecystitis [ 10 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Acalculous cholecystitis is a common extrahepatic manifestation of hepatitis E and suggests a more serious condition

et al. 2023

Virol J

Background This study aimed to understand the incidence and clinical significance of acalculous cholecystitis in patients with acute hepatitis E (HE). Patients and methods A single center enrolled 114 patients with acute HE. All patients underwent imaging of the gallbladder, and patients with gallstones and cholecystectomy were excluded. Results Acalculous cholecystitis was found in 66 patients (57.89%) with acute HE. The incidence in males was 63.95%, which was significantly higher than in females (39.29%) (P = 0.022). The mean length of hospital stay and the incidence of spontaneous peritonitis in patients with cholecystitis (20.12 ± 9.43 days and 9.09%, respectively) were significantly higher than those in patients without cholecystitis (12.98 ± 7.26 days and 0%, respectively) (P < 0.001 and P = 0.032). Albumin, total bile acid, bilirubin, cholinesterase, and prothrombin activity in patients with cholecystitis were significantly inferior to those in patients without cholecystitis (P < 0.001, P < 0.001, P < 0.001, P < 0.001 and P = 0.003, respectively). After correction by multivariate analysis, albumin and total bile acid were found to be closely related to acalculous cholecystitis in HE. Conclusion Acalculous cholecystitis is very common in patients with acute HE, and may serve as a predictor of increased peritonitis, synthetic decompensation, and longer hospital stay.

“…Metabolites of virus may invade the wall of the gallbladder or biliary epithelial cells, leading to cholestasis, which in turn results in acalculous cholecystitis (7,8). Although it was reported in 1987 that acalculous cholecystitis may be an extrahepatic complication of liver disease (9), viral hepatitis related acalculous cholecystitis is mostly reported in hepatitis A (10)(11)(12)(13)(14)(15)(16)(17), and a few are hepatitis B (18) and C (19)(20)(21). Hepatitis E related cholecystitis was not reported from a study of Qatar until 2009, but there were only two cases (22).…”

Section: Introductionmentioning

confidence: 99%

Acalculous cholecystitis is a common extrahepatic manifestation of hepatitis E and suggests a more serious condition

et al. 2022

Preprint

Background: The purpose of this study was to understand the incidence and clinical significance of acalculous cholecystitis in acute hepatitis E. Patients and methods: A single center enrolled 114 patients with acute hepatitis E. All these patients had imaging of the gallbladder, and patients with gallstones and cholecystectomy were excluded. Results: Acalculous cholecystitis was found in 66 patients (57.89%) with acute hepatitis E. The incidence of males was 63.95%, which was significantly higher than that of females (39.29%) (P=0.022). The mean hospital stays and the incidence of spontaneous peritonitis in patients with cholecystitis were significantly higher than those in patients without cholecystitis 20.12 ± 9.43 days and 9.09%, respectively, and significantly higher than those in patients without cholecystitis 12.98 ± 7.26 days and 0% (P<0.001 and P=0.032, respectively). ALB, TB, DB, CHE and PTA in patients with cholecystitis were significantly inferior to those without cholecystitis (P<0.001, P<0.001, P<0.001, P<0.001 and P= 0.003, respectively). Conclusion: Acalculous cholecystitis is very common in patients with acute hepatitis E, and it may serve as a predictor of increased peritonitis, synthetic decompensation, and longer hospital stay with hepatitis E.