Acantholytic dermatosis of the vulvocrural area

Hsu, Sylvia; Ledbetter, Leslie S.; Krishnan, R. S.; Reed, Jon A.

doi:10.1067/mjd.2003.242

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…Another entity that shows acantholytic dyskeratosis is the acantholytic dermatosis of the vulvocrural area. It typically presents as multiple papules on the perineum, inguinal folds, vulva, and perianal sites [ 6 ]. The intertriginous acantholytic dermatosis is a different clinical entity from Haley-Haley disease and intertriginous Darier's disease, although similar histopathological changes can be found.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Location of Subungual Warty Dyskeratoma: A Case Report and Review of the Literature

Vargas-Laguna

Imbernón-Moya

Aguilar-Martínez

et al. 2017

Case Reports in Dermatological Medicine

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Warty dyskeratoma is an uncommon entity characterized by a solitary keratotic papule or nodule usually located in the head and neck of young adults. The histopathology shows a pattern of acantholytic dyskeratosis. We report a 32-year-old man who presented pain, serous exudation, a distal onycholysis with subungual hyperkeratosis, and roundish erythronychia in the nail plate of his left first toe 2 years ago. A histopathologic diagnosis of subungual warty dyskeratoma was made. When dealing with focal acantholytic dyskeratosis several differential diagnoses should be considered including Darier's disease, transient focal acantholytic dyskeratosis or Grover disease, and Hailey-Hailey disease. We present an unusual location of warty dyskeratoma in the nail bed using a clinicohistopathological correlation for the diagnosis.

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Section: Discussionmentioning

confidence: 99%

An Unusual Location of Subungual Warty Dyskeratoma: A Case Report and Review of the Literature

Vargas-Laguna

Imbernón-Moya

Aguilar-Martínez

et al. 2017

Case Reports in Dermatological Medicine

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“…There are at least 16 reports of compatible cases in adult female patients, in which multiple lesions were reported as showing both acantholysis and dyskeratosis. In an additional eight women, the lesions were solitary and therefore are of uncertain relevance .…”

Section: Discussionmentioning

confidence: 99%

“…These cases have been published under various names, many as papular acantholytic dyskeratosis/dermatosis, others as acantholytic dermatosis of the vulvocrural/ anogenital area; some cases have been published under the names of histopathologically similar entities such as multiple warty dyskeratomas, 11 with subsequent commentary suggesting reclassification into the papular acantholytic dyskeratosis spectrum. 12 Lesions have been reported on the genital mucosa, external genitalia, and surrounding skin of the groin and upper thigh. Two reports also involved the chest, 6,7 prompting the suggested alternate terminology 'intertriginous acantholytic dermatosis,' 7 although this name has not been adopted.…”

Section: Discussionmentioning

confidence: 99%

Somatic ATP2A2 mutation in a case of papular acantholytic dyskeratosis: mosaic Darier disease

et al. 2015

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Papular acantholytic dyskeratosis (PAD), also known as acantholytic dermatosis of the vulvocrural (or anogenital) area, is an uncommon eruption reported predominantly in women. This entity manifests with pruritic papules in the groin/anogenital area and less commonly on the chest. The pathobiology of PAD is uncertain. A 62-year old woman presented with multiple verrucous-appearing lesions in the groin and on the chest showing acantholytic dyskeratosis on histopathology. Given histological similarity of these PAD lesions to Darier disease (DD) due to inherited ATP2A2 mutation, we screened affected and normal tissue and peripheral blood in our patient for mutations in ATP2A2. We found an identical ATP2A2 p.706D>N mutation in multiple independent PAD lesions that was not present in uninvolved skin or peripheral blood DNA. These findings establish somatic mosaicism of ATP2A2 mutations as a genetic cause for PAD.

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“…The absence of an eruption elsewhere on the body, the persistent course of the condition, and the absence of a positive family history, distinguishes acantholytic dermatosis of the vulva from Hailey-Hailey, Darier disease, or Grover'disease [4]. The differential diagnosis of a localized disease includes warty dyskeratoma and squamous cell carcinoma, which can be distinguished based on clinical and pathological features [8,9].…”

Section: Discussionmentioning

confidence: 99%