Acantholytic Dyskeratosis Consistent With Grover's Disease After Letrozole Therapy

Abstract

We present a rare case of Grover's disease (GD) associated with letrozole therapy in a 66-year-old female with stage IV breast cancer. GD is a dermatological condition characterized by papulovesicular lesions typically found on the chest and trunk. While GD is linked to chemotherapeutic agents, its association with letrozole is not well documented. The patient presented with a pruritic rash on her neck, right arm, and trunk, initially misdiagnosed as contact dermatitis. Despite treatment with triamcinolone acetonide, the rash persisted. A subsequent punch biopsy confirmed acantholytic dyskeratosis consistent with GD. Discontinuation of letrozole and treatment with augmented betamethasone dipropionate resulted in significant improvement within four weeks. This case underscores the importance of considering druginduced dermatological conditions in patients undergoing chemotherapy. While hypersensitivity drug eruptions typically present as morbilliform-patterned cutaneous eruptions, GD should be considered, especially in older patients with multiple medications. The incidence of GD following letrozole therapy is not well studied, making this case a valuable addition to the limited literature. In summary, recognizing and managing drug-induced skin conditions in cancer patients are crucial. This report contributes to our understanding of the potential association between letrozole and GD, emphasizing the need for further research in this area.

A Grover-Like Skin Rash: A Potential Indicator of Underlying Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

“…Additionally, systemic diseases or neurovegetative disruptions affecting sweat secretion may influence the disease's course [4]. The role of medications, especially chemotherapeutic agents such as docetaxel, etoposide, and daunorubicin, as well as aromatase inhibitors such as letrozole, and BRAF inhibitors have been implicated as potential triggers in drug-induced cases of Grover's disease [5,6]. Recent evidence suggests a possible link between Grover's disease and systemic infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlighting significant public health implications in the context of the coronavirus disease 2019 (COVID-19) pandemic [7].…”