Acantholytic Squamous Cell Carcinoma Arising in a Nevus Sebaceous : A Case Report

Abstract

Although nevus sebaceous (NS) is known to develop various types of secondary neoplasms, it rarely causes carcinoma and only fifteen cases of secondary squamous cell carcinoma (SCC) have been reported. We report a rare variant of SCC (acantholytic type) arising in nevus sebaceus.

Squamous Cell Carcinoma within a Congenital Nevus Sebaceous: Case Report and Literature Review

“…Of these, 2.5% were malignant neoplasms, and only four SCCs (0.57%) were found [ 3 ]. Until now, there have been a small number of cases with secondary SCC in the NS, as identified in 20 case reports and case series in English [ 2 , 3 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Clinical and Dermoscopic Features of a Rare Histologic Variant: Acantholytic Squamous Cell Carcinoma

“…Initially described in 1947 by Lever, the ASCC was considered to have a sweat gland origin, and was named adenoacanthoma of sweat glands [5]. However, later it was accepted as an uncommon variant of squamous cell carcinoma [4]. It represents 2-4% of all cutaneous squamous cell carcinoma [5], and it is usually found on the sunexposed areas of elderly patients with notable male predominance [2].…”

“…Acantholytic squamous cell carcinoma (ASCC) is an uncommon variant of squamous cell carcinoma (SCC) [1], in which significant portions of the neoplastic proliferation show a pseudoglandular or tubular microscopic pattern [2]. This variant is also known as adenoid SCC, adenoacanthoma of sweat glands, and pseudoglandular SCC [3], and few cases have been reported in literature [4]. The most frequent locations of the tumor are the sun exposed ones, however many other different sites have been reported [5].…”