Acantholytic squamous cell carcinoma of the gingiva: report of a case and review of the literature

Papadopoulou, Erofili; Tosios, Konstantinos I.; Nikitakis, Nikolaos G.; Papadogeorgakis, Nikolaos; Sklavounou‐Andrikopoulou, Alexandra

doi:10.1016/j.tripleo.2010.01.019

Cited by 32 publications

(36 citation statements)

References 16 publications

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“…Most reported cases arise from gingiva, tongue, floor of the mouth and buccal mucosa [4,6,10]. Except in the lip (perhaps due to early detection and treatment), the head and neck mucosal ASCCs reported were associated with poor prognoses.…”

Section: Introductionmentioning

confidence: 99%

Acantholytic Squamous Cell Carcinoma in Upper Aerodigestive Tract: Histopathology, Immunohistochemical Profile and Epithelial Mesenchymal Transition Phenotype Change

Jiang

Fowler

2012

Head and Neck Pathol

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Acantholytic squamous cell carcinoma is a rare variant of squamous cell carcinoma in the mucosa of upper aerodigestive tract. Histomorphologically, acantholytic squamous cell carcinoma may lose the typical features of conventional squamous cell carcinoma and mimic other epithelial or mesenchymal malignancies due to advanced acantholysis and dyskeratosis. Because of its rarity, information of prognosis, pathologic features and immunohistochemical profiles is limited. We have studied clinicopathologic features and immunohistochemical profiles of four acantholytic squamous cell carcinoma cases arising from upper aerodigestive tract. Clinical results indicate an aggressive biologic behavior. Morphologically, all tumors revealed significant acantholysis with separation of tumor cells and intratumoral spaces. The tumor cells were highly pleomorphic and growth patterns were variable. In immunohistochemical studies, all tumor cells revealed positive reactions for AE1/AE3 and p63 supporting a squamous epithelial origin. In contrast to conventional aerodigestive squamous cell carcinoma, acantholytic squamous cell carcinoma showed significant reductions of cytokeratin19, E-cadherin and concomitant up-regulation of vimentin expression. Both morphologic features and immunohistochemical profiles indicate that acantholytic squamous cell carcinoma has acquired an epithelial mesenchymal transition phenotype. However, in contrast to other solid malignant tumors, the epithelial mesenchymal transition phenotype change in acantholytic squamous cell carcinoma is not limited to the invasive front of the peripheral tumor but, rather, diffusely involves entire neoplastic lesion. In addition, because cytokeratin 19 staining is attenuated, this would be an insensitive marker for following up and/or in detecting disseminated tumor cells in cases of acantholytic squamous cell carcinoma in upper aerodigestive tract.

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Section: Introductionmentioning

confidence: 99%

Acantholytic Squamous Cell Carcinoma in Upper Aerodigestive Tract: Histopathology, Immunohistochemical Profile and Epithelial Mesenchymal Transition Phenotype Change

Jiang

Fowler

2012

Head and Neck Pathol

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“…8 Several oral ASCCs have been identified at other sites, including the buccal mucosa, floor of mouth, and tongue. 9,10 These lesions are reported to have a poorer prognosis than conventional SCC at the same site. 5,9,11 Most of our accumulated knowledge in this regard is based on a handful of case reports with little follow-up information with which to reach definitive conclusions regarding the biologic behavior.…”

Section: Discussionmentioning

confidence: 99%

Adenoid dysplasia of the oral mucosa

Bunn

Hunter

Khurram

et al. 2014

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective. To describe an unusual variant of oral epithelial dysplasia and to provide an appraisal of its immunohistochemical profile. Study Design. An unusual form of epithelial dysplasia, which we have termed adenoid dysplasia, was evaluated for staining of cytokeratins AE1/AE3, vimentin, E-cadherin, and b-catenin. The immunohistochemical results were compared with those observed in moderate epithelial dysplasia, moderately differentiated squamous cell carcinoma, and acantholytic squamous cell carcinoma.Results. The immunoprofile of adenoid dysplasia was similar to that of acantholytic squamous cell carcinoma. Cytokeratin positivity within the acantholytic dysplastic cells confirmed their epithelial nature, and upregulation of vimentin was suggestive of epithelial-mesenchymal transition. The most distinctive finding was a loss of E-cadherin expression within the discohesive cells, accompanied by increased cytosolic expression of b-catenin.Conclusions. This report presents the histomorphologic features of a unique form of oral epithelial dysplasia, termed adenoid dysplasia.

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“…PSCC is now considered to be a variant of squamous cell carcinoma, identified using both immunohistochemical and electron microscopy studies, 4 and has been reported in different organs including the penis, and head-and-neck region. 14,16,17,19,20 Since the first published case of pulmonary PSCC in 1992, 4 only five additional cases of PSCC of the lung have been reported. 5,7,8 In 2004, the World Health Organization classified these rare squamous cell carcinomas with an angiosarcomatoid character as pleomorphic carcinoma, defined as a type of sarcomatoid carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…3, 13,15,18,20 Metastases within and outside of the thoracic cavity are common, and metastases in liver, adrenal glands and ribs following pulmonary PSCC have been reported. 7,8 Life expectancy postdiagnosis ranged from 5 to 34 months in one publication 7 but, at ≤ 3 months, was considerably shorter in the two new cases reported here.…”

Section: Discussionmentioning

confidence: 99%

Pseudoangiosarcomatous Squamous Cell Carcinoma of the Lung

et al. 2011

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Pulmonary pseudoangiosarcomatous squamous cell carcinoma (PSCC) is a rare aggressive variant of squamous cell carcinoma. Histopathologically, PSCC is characterized by interanastomosing cords and channels, lined by atypical cells, with spaces containing erythrocytes or floating tumour cells. PSCC mimics angiosarcoma, so careful attention should be paid to immunohistochemical differences. Two PSCC cases are described here: in a 79-year-old male, bronchoscopy revealed mucosal swelling and hypertrophy and an adrenal mass was found 1 month later; in a 76-year-old male, computed tomography revealed rib destruction due to a non-calcified softtissue tumour and, although the tumour resembled an angiosarcoma, endothelial markers were negative and cytokeratin and p63 markers were positive. Immunohisto chemical analyses may be helpful in establishing an accurate diagnosis. PSCC had a progressive course in both patients, who died ≤ 3 months postdiagnosis.

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Acantholytic squamous cell carcinoma of the gingiva: report of a case and review of the literature

Cited by 32 publications

References 16 publications

Acantholytic Squamous Cell Carcinoma in Upper Aerodigestive Tract: Histopathology, Immunohistochemical Profile and Epithelial Mesenchymal Transition Phenotype Change

Acantholytic Squamous Cell Carcinoma in Upper Aerodigestive Tract: Histopathology, Immunohistochemical Profile and Epithelial Mesenchymal Transition Phenotype Change

Adenoid dysplasia of the oral mucosa

Pseudoangiosarcomatous Squamous Cell Carcinoma of the Lung

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