Acanthopanax henryi: Review of Botany, Phytochemistry and Pharmacology

Li, Xiaojun; Tang, Siqi; Huang, Hao; Luo, Jiao; Zhang, Xiaodan; Yook, Chang‐Soo; Whang, Wan Kyunn; Kim, Youn‐Chul; Liu, Xiangqian

doi:10.3390/molecules26082215

Cited by 21 publications

(10 citation statements)

References 19 publications

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“…Relevant studies [ 34 ] have shown that the methanol extract of ASH has a certain inhibitory effect on some cancers and many components of it are used in a variety of drugs. Compound cantharidin capsule has been mainly used for the treatment of rectal cancer, lung cancer, malignant lymphoma, primary liver cancer, and gynecological malignant tumor [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways

et al. 2022

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Background Breast cancer (BC) is one of the most common malignant tumors with the highest mortality in the world. Modern pharmacological studies have shown that Syringin has an inhibitory effect on many tumors, but its anti-BC efficacy and mechanism are still unclear. Methods First, Syringin was isolated from Acanthopanax senticosus (Rupr. & Maxim.) Harms (ASH) by systematic solvent extraction and silica gel chromatography column. The plant name is composed of genus epithet, species additive words and the persons’ name who give its name. Then, the hub targets of Syringin against BC were revealed by bioinformatics. To provide a more experimental basis for later research, the hub genes which could be candidate biomarkers of BC and a ceRNA network related to them were obtained. And the potential mechanism of Syringin against BC was proved in vitro experiments. Results Syringin was obtained by liquid chromatography-mass spectrometry (LC–MS), nuclear magnetic resonance (NMR), and high-performance liquid chromatography (HPLC). Bioinformatics results showed that MAP2K1, PIK3CA, HRAS, EGFR, Caspase3, and PTGS2 were the hub targets of Syringin against BC. And PIK3CA and HRAS were related to the survival and prognosis of BC patients, the PIK3CA-hsa-mir-139-5p-LINC01278 and PIK3CA-hsa-mir-375 pathways might be closely related to the mechanism of Syringin against BC. In vitro experiments confirmed that Syringin inhibited the proliferation and migration and promoted apoptosis of BC cells through the above hub targets. Conclusions Syringin against BC via PI3K-AKT-PTGS2 and EGFR-RAS-RAF-MEK-ERK pathways, and PIK3CA and HRAS are hub genes for adjuvant treatment of BC. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways

et al. 2022

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“…Relevant studies [31] have shown that the methanol extract of AS has a certain inhibitory effect on some cancers and many components of it are used in a variety of drugs. Compound cantharidin capsule has been mainly used for the treatment of rectal cancer, lung cancer, malignant lymphoma, primary liver cancer, and gynecological malignant tumor [32].…”

Section: Discussionmentioning

confidence: 99%

Syringin Exerts Anti-Breast Cancer Effects Through PI3K-AKT and EGFR-RAS-RAF Pathways

Wang

Yuan

Liu

et al. 2022

Preprint

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Background Breast cancer (BC) is one of the most common malignant tumors with the highest mortality in the world. Modern pharmacological studies have shown that Syringin has an inhibitory effect on many tumors, but its anti-BC efficacy and mechanism are still unclear. Methods First, Syringin was isolated from Acanthopanax senticosus (Rupr. & Maxim.) Harms (AS) by systematic solvent extraction and silica gel chromatography column. Then, the potential mechanism of syringin against BC was revealed by bioinformatics and in vitro experiments. To provide a more experimental basis for later research, the hub genes which could be candidate biomarkers of BC and a ceRNA network related to them were obtained. Results Syringin was obtained by liquid chromatography-mass spectrometry (LC-MS), nuclear magnetic resonance (NMR), and high-performance liquid chromatography (HPLC). Bioinformatics results showed that MAP2K1, PIK3CA, HRAS, EGFR, Caspase3, and PTGS2 were the hub targets of Syringin against BC. In vitro experiments confirmed that Syringin inhibited the proliferation and migration and promoted apoptosis of BC cells through the above hub targets. And PIK3CA and HRAS were related to the survival and prognosis of BC patients, the PIK3CA-has-mir-139-5p-LINC01278 and PIK3CA-has -mir-375 pathways might be closely related to the mechanism of Syringin against BC. Conclusions Syringin against BC via PI3K-AKT-PTGS2 and EGFR-RAS-RAF-MEK-ERK pathways, and PIK3CA and HRAS are hub genes for adjuvant treatment of BC.

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“…Eleutherococcus henryi Oliv. is a well-known TCM, which is commonly used to treat mental fatigue and amnesia, as well as inflammatory conditions, including rheumatism, arthritis, and hepatitis [ 15 , 16 ] (The plant name has been checked with World Flora Online ( , accessed on 26 August 2022) and Medicinal Plant Names Services ( , accessed on 26 August 2022). Savinin is a natural lignan isolated from the roots of E. henryi ( Figure 1 ) [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Savinin on LPS-Induced Neuroinflammation In Vivo via Regulating MAPK/NF-κB Pathway and NLRP3 Inflammasome Activation

Tang

Suo

et al. 2023

Molecules

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The traditional herb Eleutherococcus henryi Oliv. is commonly used to treat inflammatory conditions including rheumatism, arthritis, and hepatitis, as well as mental fatigue and amnesia, according to traditional Chinese medicine (TCM) theory. Savinin is a natural lignan obtained from the roots of E. henryi. The present study was undertaken to determine whether savinin can relieve LPS-induced neuroinflammation and if so, what the mechanism is. Groups of male C57BL/6 mice were administered savinin (5, 10, 20 mg/kg) and DEX (10 mg/kg) by gavage once daily for a continuous 7 days. On the 5th day of continuous pre-administration, LPS (2.5 mg/kg) was injected into the lateral ventricles of the mice for modeling 48 h. We found that treatment with savinin decreased the levels of neuroinflammatory cytokines and histopathological alterations dramatically. Consequently, it improved the LPS-induced neuroinflammatory response in mice. Furthermore, savinin inhibited the up-regulated expression of related proteins in the activated MAPK/NF-κB and NLRP3 inflammasome signaling pathways caused by LPS. Docking studies demonstrated the binding of savinin to three receptors (MAPK, NF-κB and NLRP3) using a well-fitting mode. These findings suggest that savinin may suppress neuroinflammation induced by LPS in vivo via modulating MAPK/NF-κB and NLRP3 signaling pathways.

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Acanthopanax henryi: Review of Botany, Phytochemistry and Pharmacology

Cited by 21 publications

References 19 publications

Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways

Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways

Syringin Exerts Anti-Breast Cancer Effects Through PI3K-AKT and EGFR-RAS-RAF Pathways

Neuroprotective Effects of Savinin on LPS-Induced Neuroinflammation In Vivo via Regulating MAPK/NF-κB Pathway and NLRP3 Inflammasome Activation

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