Acanthopanax senticosus Extract Acts as an Important Regulator for Vascular Functions.

Choi, Seong-Soo; Park, Jong-Bong; Kim, Jong Min; In, Kyung-Min; Park, Heon-Yong

doi:10.5352/jls.2008.18.5.701

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…Lipopolysaccharide (LPS)는 그람양성균 세포벽 외막를 구성하는 주요 성분으로 염증반응을 유도한다 [18]. 백혈구와 혈관내피세포에 LPS를 처리한 후 배양하면 염 산화질소 생산 측정 실험결과 산화질소는 다양한 생리적 기능을 하지만 특히 혈관계와 관련 지어 혈관확장, 혈소판 응집 억제, 호중구의 부착 억제 [15] 및 동맥경화 발생 억제와 같은 기능을 하는 다양한 혈관 조절 인자이다 [5]. 혈관내피세포에서 산화질소는 eNOS에 의 해 L-arginine으로부터 합성된다 [4].…”

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Effect of Alliin on Vascular Functions

2009

Journal of Life Science

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Yongin-si, Gyeonggi-do, 448-701, Korea -Little is known about the cardiovascular roles of alliin, a functional component in garlic that has been used as food material. Thus, we examined a broad range of cardiovascular activities of alliin in this study. From our in vitro experiments, alliin was determined to act as a stimulant to induce endothelial cell proliferation and endothelial cell migration. Since endothelial cell proliferation and migration are highly associated with angiogenesis and wound healing, alliin is suggested as a regulator to control angiogenesis and wound healing. In addition, alliin was elucidated to prevent lipopolysaccharide (LPS)-induced adhesion of THP-1 leukocytes to endothelial cells and LPS-induced homotypic THP-1 cell aggregation. These inhibitory effects indicate that alliin is likely to act as an anti-atherosclerotic and anti-thrombotic factor, because leukocytic adhesion to endothelial cells and homotypic leukocyte aggregation are highly associated with atherosclerosis and thrombosis, respectively. Our additional findings show that alliin has no effect on the production of nitric oxide (NO), an important vasoregulator. In conclusion, alliin is suggested as a regulator for controlling various cardiovascular functions.

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Effect of Alliin on Vascular Functions

2009

Journal of Life Science

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Extract fromAcanthopanax senticosusprevents LPS-induced monocytic cell adhesion via suppression of LFA-1 and Mac-1

Kim

McLean

Pyee

et al. 2014

Can. J. Physiol. Pharmacol.

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A crude extract from Acanthopanax senticosus (AS) has drawn increased attention because of its potentially beneficial activities, including anti-fatigue, anti-stress, anti-gastric-ulcer, and immunoenhancing effects. We previously reported that AS crude extract exerts anti-inflammatory activity through blockade of monocytic adhesion to endothelial cells. However, the underlying mechanisms remained unknown, and so this study was designed to investigate the pathways involved. It was confirmed that AS extract inhibited lipopolysaccharide (LPS)-induced adhesion of monocytes to endothelial cells, and we found that whole extract was superior to eleutheroside E, a principal functional component of AS. A series of PCR experiments revealed that AS extract inhibited LPS-induced expression of genes encoding lymphocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1) in THP-1 cells. Consistently, protein levels and cell surface expression of LFA-1 and Mac-1 were noticeably reduced upon treatment with AS extract. This inhibitory effect was mediated by the suppression of LPS-induced degradation of IκB-α, a known inhibitor of nuclear factor-κB (NF-κB). In conclusion, AS extract exerts anti-inflammatory activity via the suppression of LFA-1 and Mac-1, lending itself as a potential therapeutic galenical for the prevention and treatment of various inflammatory diseases.

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Seasonal Variation of Phenolic Component Contents in the Stems of Korean Acanthopanax senticosus

Kim

Yang

2023

JKOMOR

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Objectives: The aim of this study was to compare the total phenolic content of Korean Acanthopanax senticosus stems harvested in different seasons and provide basic data for developing functional reinforcement products based on the optimal harvesting time. Methods: Each sample harvested in different seasons was extracted and concentrated twice for 2 hours using 70% ethyl alcohol. Phenolic compounds were analyzed using high-performance liquid chromatography for simultaneous multi-component analysis of 14 compounds, including syringaresinol and so on. Results: The results showed that the stem of Korean Acanthopanax senticosus harvested in winter (November 29th) (EAS-5) had the highest phenolic content of 1.038%. The stem of Korean Acanthopanax senticosus harvested in autumn (October 1st) (EAS-4) showed the second-highest phenolic content of 0.764%, followed by the stem of Korean Acanthopanax senticosus harvested in spring (February 2nd) (EAS-1) with a content of 0.390%. On the other hand, the stem of Korean Acanthopanax senticosus harvested in the summer (June 2nd) (EAS-3) showed the lowest content at 0.342%. In conclusion, the stem of Korean Acanthopanax senticosus harvested in winter (EAS-5) showed the highest phenolic compound content. Conclusions: Considering the extraction yield and the total phenolic content, as well as the concentrations of key functional components such as eleutheroside B, chlorogenic acid, and syringaresinol in the 70% ethyl alcohol extract of Korean Acanthopanax senticosus, it is suggested that the stems of Korean Acanthopanax senticosus harvested during the winter season are suitable for the development of novel materials with enhanced anti-obesity functionality.

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Acanthopanax senticosus Extract Acts as an Important Regulator for Vascular Functions.

Cited by 6 publications

References 17 publications

Effect of Alliin on Vascular Functions

Effect of Alliin on Vascular Functions

Extract fromAcanthopanax senticosusprevents LPS-induced monocytic cell adhesion via suppression of LFA-1 and Mac-1

Seasonal Variation of Phenolic Component Contents in the Stems of Korean Acanthopanax senticosus

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