Acanthopanax trifoliatus, a Potential Adaptogenic Thai Vegetable for Health Supplement

Sithisarn, Pongtip; Jarikasem, Siripen; Thisayakorn, Krittiya

doi:10.5772/27762

Cited by 10 publications

(11 citation statements)

References 36 publications

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“…Suree NANASOMBAT et al http://wjst.wu.ac.th northern of Thailand, young leaves and the shoots of this plant are usually consumed as vegetable [54]. For antioxidant activity of kamchat ton (Z. limonella), it was probably due to its active compounds.…”

Section: Antidiabetic and Antioxidant Activities Of Thai Plantsmentioning

confidence: 99%

Evaluation of Antidiabetic, Antioxidant and Other Phytochemical Properties of Thai Fruits, Vegetables and Some Local Food Plants

Nanasombat

Yansodthee

Jongjaited

2019

Walailak J Sci & Tech

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Antidiabetic, antioxidant, anti-acetylcholinesterase and prebiotic activities, total phenolics and flavonoids of 33 crude ethanolic extracts of Thai local fruits, vegetables and some local food plants were determined. Mangosteen (Garcinia mangostana) fruit peel and Indian gooseberry (Phyllanthus emblica) fruit extracts had highest antioxidant activity. Bamboo grass (Tiliacora triandra) leaf extract had strongest α-amylase inhibitory activity (78.28 % inhibition), while mulberry (Morus alba) fruit extract had strongest α-glucosidase inhibitory activity (59.63 % inhibition). Star cactus (Aloe vera) leaf pulp extract had strongest anti-acetylcholinesteraseVactivity (31.55 % inhibition). Indian gooseberry fruit and mangosteen fruit peel extracts had highest content of total phenolics and flavonoids, respectively. The extract with highest indigestible polysaccharide content was the extract of mangosteen fruit peels (188.62 mg/g extract), while those with relatively high indigestible polysaccharides were the extracts of pineapple fruits (Ananas comosus), lotus seeds (Nelumbo nucifera), black rice grains (Oryza sativa) and pisang mas banana fruits (Musa sapientum). Based on these properties, 5 plant extracts were selected to study for their prebiotic effect on growth and fermentation of Lactobacillus acidophilus, Lactobacillus bulgaricus and Streptococcus thermophilus in yogurt at 42 °C. Addition of lotus seed extract resulted in highest proliferation of these bacteria with 2.24 logCFU/g increase of total lactic acid bacterial counts in yogurt after 24 h fermentation, while addition of black rice grain, pisang mas banana fruit and pineapple fruit extracts caused good growth of these bacteria with 2.12 - 2.19 logCFU/g increase of total counts.

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Section: Antidiabetic and Antioxidant Activities Of Thai Plantsmentioning

confidence: 99%

Evaluation of Antidiabetic, Antioxidant and Other Phytochemical Properties of Thai Fruits, Vegetables and Some Local Food Plants

Nanasombat

Yansodthee

Jongjaited

2019

Walailak J Sci & Tech

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“…In other studies, the ACK molecule has been referred to as acankoreanogenin, which is apparently the name it was first given when the compound was initially isolated from A. gracilistylus 59,60 and later from A. trifoliatus 61 . The compound has revealed potent anti‐inflammatory activities in vitro and in vivo , notably in a mice model of fulminant hepatitis, reducing the serum levels of inflammatory cytokines (TNF‐α and IL‐1β) and dose‐dependently attenuating the release of the protein HMGB1 51 .…”

Section: Ack and Related Sapogeninsmentioning

confidence: 99%

Acankoreagenin and acankoreosides, a family of lupane triterpenoids with anti‐inflammatory properties: an overview

Bailly¹

2021

Annals of the New York Academy of Sciences

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Acankoreagenin (ACK, also known as acankoreanogenin and HLEDA) and impressic acid are two lupane‐type triterpenes that can be isolated from various Acanthopanax and Schefflera species. They efficiently block activation of the NF‐κB signaling pathway and the release of proinflammatory cytokines and/or the action of inflammation mediators (HMGB1, iNOS, and NO). These effects are the basis for the antiviral and anticancer activities reported with these pentacyclic compounds or their various glycoside derivatives. More than 15 acankoreosides (Ack‐A to ‐O, and ‐R) and a few other mono‐ and bidesmosidic saponins (acantrifoside A and acangraciliside S) derive from the ACK aglycone. Compounds like Ack‐A and ‐B are remarkable anti‐inflammatory agents, inhibiting cytokine release from activated macrophages. Despite their effectiveness, ACK and impressic acid are far much less known and studied than the structurally related compounds betulinic acid and 23‐hydroxybetulinic acid (anemosapogenin). The structural differences (notably the R/S stereoisomerism of the 3‐hydroxyl group) and functional similarities of these compounds are discussed. The complete series of acankoreosides is presented for the first time. These natural products deserve further attention as anti‐inflammatory agents, and ACK is recommended as a template for the design of new anticancer and antiviral drugs.

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“…is a shrub that belongs to the family Araliaceae and is widely distributed in India, Japan, the Philippines, Thailand, Vietnam, and many provinces of China (eFloras 2008). Some plants in the family Araliaceae are used in the folk medicines of south-east Asia as a medicinal and edible plant with ginseng-like activity, for example, the leaves and bark of A. trifoliatus have been used as a tonic to improve general weakness (Sithisarn et al 2011). Moreover, young leaves and shoots of A. trifoliatus are popularly consumed in southern China and northern Thailand as vegetables (Sithisarn et al 2011), which can be stir-fried or cooked in soup.…”

Section: Introductionmentioning

confidence: 99%

Terpenoid composition and the anticancer activity of Acanthopanax trifoliatus

Zheng

Chen

et al. 2015

Arch. Pharm. Res.

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The petroleum ether and ethyl acetate fractions of extract from an edible and medicinal plant Acanthopanax trifoliatus were found to show significant inhibitory effects against SF-268, MCF-7, HepG2 and NCI-H460 cancer cells. Two new ursane-type triterpenoids, acantrifoic acid C (1) and acantrifoic acid D (2), along with five known triterpenoids (3-7) and eight known diterpenoids (8-15) were obtained from these two fractions. To the best of our knowledge, this is the first report concerning the isolation of compounds (5-12, 14, 15) from A. trifoliatus. Among all the isolated compounds, 3, 5 and 8 from the ethyl acetate fraction showed the strongest inhibitory effects against cancer cells, while 12 and 13 from the petroleum ether fraction showed moderate activities. These terpenoid compounds may be responsible for the anticancer activities of A. trifoliatus. Our study provides the first evidence that terpenoids from A. trifoliatus exert anticancer activities and indicates that A. trifoliatus may be a useful edible plant for further development of anticancer health supplement.

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Acanthopanax trifoliatus, a Potential Adaptogenic Thai Vegetable for Health Supplement

Cited by 10 publications

References 36 publications

Evaluation of Antidiabetic, Antioxidant and Other Phytochemical Properties of Thai Fruits, Vegetables and Some Local Food Plants

Evaluation of Antidiabetic, Antioxidant and Other Phytochemical Properties of Thai Fruits, Vegetables and Some Local Food Plants

Acankoreagenin and acankoreosides, a family of lupane triterpenoids with anti‐inflammatory properties: an overview

Terpenoid composition and the anticancer activity of Acanthopanax trifoliatus

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