Acanthophoraine A, a new pyrrolidine alkaloid from the red alga Acanthophora spicifera

Abstract

A new pyrrolidine alkaloid, acanthophoraine A (1), along with six known alkaloids (2-7), had been isolated from the red alga Acanthophora spicifera. The structures of these compounds were identified by spectroscopic analyses. The absolute configuration of 1 was established by ECD calculation.Compound 1 represents the first example of N-isobutyl pyrrolidone with an urea arm. The antimicrobial activity of 1 was also evaluated.

Marine natural products

“…Three macrolides 898–900 with limited structural relatedness were reported, 401 while one pyrrolidine alkaloid, acanthophoraine A 901 , was isolated from Acanthophora spicifera . 402…”

Three New Butenolides from the Green Alga Caulerpa racemosa var. turbinata

“…In our ongoing search for biological marine natural products, three new butenolides, caulerpalide A ( 1 ), (+)‐caulerpalide B ((+)‐ 2 ) and (−)‐caulerpalide B ((−)‐ 2 ), together with seven known compounds ( 3 – 9 ), had been isolated from the alga C. racemosa var. turbinata , the chemical investigation of which had never been reported before ( Figure ).…”